373387-20-3Relevant academic research and scientific papers
Bicyclic imidazole-4-one derivatives: A new class of antagonists for the orphan G protein-coupled receptors GPR18 and GPR55
Rempel,Atzler,Behrenswerth,Karcz,Schoeder,Hinz,Kaleta,Thimm,Kiec-Kononowicz,Müller
, p. 632 - 649 (2014/05/06)
GPR18 and GPR55 are orphan G protein-coupled receptors (GPCRs) that interact with certain cannabinoid (CB) receptor ligands. In the present study bicyclic imidazole-4-one derivatives were discovered as new scaffolds for the development of antagonists for
Synthesis of 5-arylidene-2-amino-4-azolones and evaluation of their anticancer activity
Subtel'Na, Ivanna,Atamanyuk, Dmytro,Szymanska, Ewa,Kiec-Kononowicz, Katarzyna,Zimenkovsky, Borys,Vasylenko, Olexandr,Gzella, Andrzej,Lesyk, Roman
scheme or table, p. 5090 - 5102 (2010/09/06)
Series of novel 5-arylidene-2-arylaminothiazol-4(5H)-ones and 2-aryl(benzyl)amino-1H-imidazol-4(5H)-ones were synthesized from appropriate 2-alkylthioazol-4-ones using nucleophilic substitution in position 2 by various anilines and benzylamines and Knoeve
Imidazo[2,1-b]thiazepines: Synthesis, structure and evaluation of benzodiazepine receptor binding
Kiec-Kononowicz, Katarzyna,Karolak-Wojciechowska, Janina,Michalak, Barbara,Pekala, Elzbieta,Schumacher, Britta,Mueller, Christa E.
, p. 205 - 218 (2007/10/03)
As a continuation of our search for new ligands acting on benzodiazepine receptors among the fused 2-thiohydantoin derivatives, a series of 5-substituted imidazo[2,1-b]thiazepines was synthesized and investigated in radioligand binding studies at the benz
Imidazo-thiazine, -diazinone and -diazepinone derivatives. Synthesis, structure and benzodiazepine receptor binding
Kiec-Kononowicz, Katarzyna,Karolak-Wojciechowska, Janina,Mueller, Christa E.,Schumacher, Britta,Pekala, Elzbieta,Szymanska, Ewa
, p. 407 - 419 (2007/10/03)
In our search for new compounds acting on benzodiazepine receptors among the fused 2-thiohydantoin derivatives, a series of arylidene imidazo[2,1-b]thiazines was synthesized. The 1,2- and 2,3- cyclized derivatives of mono- and di-substituted Z-5-arylidene-2-thiohydantoins were examined (the X-ray crystal structure of Z-2-cinnamylidene-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-3(2H)-one was determined) and compared with the diphenyl derivatives. To investigate the influence of the type of annelated ring on the biological activity, imidazo[2,1-b]pyrimidinone and imidazo[2,1-b]diazepinone derivatives were obtained. The method used in annelation (1,2- and 2,3-cyclized isomers with the exception of fused arylidene imidazothiazines), the substitution pattern (arylidene towards diphenyl) as well as the character of the annelated ring had minor influence on the benzodiazepine receptor affinity of the investigated compounds. It appears that the greatest influence on the biological activity has the character and position of the substituents on the arylidene ring.
