373622-99-2

Upstream product

• 373622-98-1 4-Amino-2-benzoyl-2'-methoxymethoxy-6'-methoxy-biphenyl 
• 57234-28-3 1-methoxy-3-(methoxymethoxy)benzene 
• 373622-95-8 2-bromo-N-methoxy-N-methyl-5-nitrobenzamide 
• 373622-97-0 N-methoxy-N-methyl-4-amino-2'-methoxymethoxy-6'methoxy-biphenyl-2-carboxamide 
• 373622-96-9 N-methoxy-N-methyl-4-nitro-2'-methoxymethoxy-6'-methoxy-biphenyl-2-carboxamide 

Downstream Products

• 373623-00-8 8-Amino-1-methoxy-6-phenyl-6H-dibenzo[b,d]pyran 

Relevant academic research and scientific papers

Synthesis and biological evaluation of novel, selective, nonsteroidal glucocorticoid receptor antagonists

We report the discovery of a novel class of glucocorticoid receptor (GR) antagonists based on the chromene molecular scaffold. The compounds exhibit good functional potency and an improved receptor selectivity profile for GR over other steroid receptors when compared to the classical steroidal GR-antagonist, RU-486.

Glucocorticoid receptor antagonists for treatment of diabetes

Compounds of formula I are useful for treating type II diabetes, obesity, hyperglycemia, inadequate glucose clearance, hyperinsulinemia, hypertriglyceridemia, and high-circulating glucocorticoid levels, preparations of the compounds, compositions containing the compounds, and methods of treatment using the compounds.

GLUCOCORTICOID RECEPTOR ANTAGONISTS FOR TREATMENT OF DIABETES

are useful for treating type II diabetes, obesity, hyperglycemia, inadequate glucose clearance, hyperinsulinemia, hypertriglyceridemia, and high-circulating glucocorticoid levels, preparations of the compounds, compositions containing the compounds, and methods of treatment using the compounds.