37389-84-7

Upstream product

• 2286-55-7 ethyl α-cyano-β-(3,4-dimethoxyphenyl)acrylate 
• 21852-32-4 4-bromomethyl-1,2-dimethoxybenzene 
• 372-09-8 cyanoacetic acid 

Downstream Products

• 65708-36-3 α-Carbethoxy-α-diethoxymethyl-β-[3,4-dimethoxyphenyl]propionitrile 
• 1196886-23-3 ethyl 2-(2-amino-5-nitro-6-oxo-1,6-dihydropyrimidin-4-yl)-2-cyano-3-(3,4-dimethoxyphenyl)propanoate 
• 1196886-25-5 2-(2-amino-5-nitro-6-oxo-1,6-dihydropyrimidin-4-yl)-3-(3,4-dimethoxyphenyl)propanenitrile 
• 1196886-27-7 7-(3,4-dimethoxybenzyl)-2-amino-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one 
• 1196881-88-5 7-(3,4-dimethoxybenzyl)-4-chloro-5H-pyrrolo[3,2-d]pyrimidin-2-amine 
• 1196881-90-9 7-(3,4-dimethoxybenzyl)-4-chloro-5-(4-methylpentyl)-5H-pyrrolo[3,2-d]pyrimidin-2-amine 
• 55502-61-9 2-cyano-3-(3,4-dimethoxyphenyl)propionic acid 

Relevant academic research and scientific papers

Asymmetric Reaction of p-Quinone Diimide: Organocatalyzed Michael Addition of α-Cyanoacetates

Hitherto unknown catalytic enantioselective transformation of p-quinone diimides is achieved using chiral bifunctional organic molecules. Bifunctional thiourea compounds catalyze the Michael addition of cyanoacetates with excellent yields and enantioselec

BIOACTIVE COMPOUNDS FOR TREATMENT OF CANCER AND NEURODEGENERATIVE DISEASES

The invention provides bioactive compounds for the treatment of various malconditions such as cancer and neurodegenerative diseases including Alzheimer's disease. The chemical compounds as disclosed herein are found to show bioactivity in bioassays related to these conditions. Pharmaceutical compositions, combinations and methods of synthesis are provided, as are methods of using the compound, compositions and combinations in the treatment of the diseases.

3-Butyl-1-methylimidazolinium borohydride ([bmim][BH4])-a novel reducing agent for the selective reduction of carbon-carbon double bonds in activated conjugated alkenes

A novel ionic reducing reagent, 3-butyl-1-methylimidazolium borohydride ([bmim][BH4]), was synthesized and successfully used for the selective reduction of carbon-carbon double bonds in conjugated alkenes as well as the α,β-carbon-carbon double bonds in highly activated α,β,γ,δ-unsaturated alkenes. The reagent can be regenerated and reused several times without losing its activity.

Benzyl cyanoacetals

Benzyl cyanoacetals of formula: STR1 wherein R1, R2 and R3 are the same or different and each is a halogen or a hydrogen atom, an alkoxy group, an alkyl group, or a dialkylamino group; R4 is an alkoxycarbonyl group, or an aldehyde group; And R5 is an alkyl group; the alkyl or alkoxy groups each having from 1 to 4 carbon atoms, and their use as intermediates in the preparation of antibacterial 2,4-diamino-5-benzylpyrimidines. They are prepared from a reaction between an orthoester and an α-substituted-β-benzylpropionitrile and then the resulting cyanoacetal is converted to the benzyl-pyrimidine by reaction with guanidine.