374081-68-2

Upstream product

• 13035-61-5 1,2,3,5-tetraacetylribose 
• 374081-64-8 3-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3H-8-thia-1,3,4,6-tetraaza-cyclopenta[a]inden-7-ol 
• 374081-65-9 3-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3H-8-thia-1,3,4,6-tetraaza-cyclopenta[a]indene-7-thiol 
• 100-39-0 benzyl bromide 
• 374081-64-8 3-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3H,6H-8-thia-1,3,4,6-tetraaza-cyclopenta[a]inden-7-one 
• 374081-65-9 3-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3H,6H-8-thia-1,3,4,6-tetraaza-cyclopenta[a]indene-7-thione 
• 374081-66-0 3-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-7-methylsulfanyl-3H-8-thia-1,3,4,6-tetraaza-cyclopenta[a]indene 
• 374081-63-7 6-amino-1-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-1H-thieno[2,3-d]imidazole-5-carboxylic acid amide 
• 374081-62-6 2-[1-((2R,3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-5-cyano-1H-imidazol-4-ylsulfanyl]-acetamide 
• 374081-61-5 3-((2R,3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-5-bromo-3H-imidazole-4-carbonitrile 
• 374081-60-4 3-((2R,3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-5-bromo-3H-imidazole-4-carbaldehyde oxime 
• 374081-58-0 1-((2R,3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-4,5-dibromo-1H-imidazole 
• 374081-59-1 3-((2R,3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-5-bromo-3H-imidazole-4-carbaldehyde 
• 437614-21-6 4,5-dibromo-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)imidazole 

Relevant academic research and scientific papers

"Fleximers". Design and synthesis of a new class of novel shape-modified nucleosides(1).

A new class of shape-modified nucleosides is introduced. These novel "fleximers" feature the purine ring systems of adenosine, inosine, and guanosine split into their individual imidazole and pyrimidine components (as in 1-3). This structural modification serves to introduce flexibility into the nucleoside while still retaining the elements essential for recognition. As a consequence, these novel fleximers should find use as bioprobes for investigating enzyme-coenzyme binding sites as well as nucleic acid and protein interactions. Their design and synthesis are described.

"Fleximers". Design and synthesis of two novel split nucleosides.

[structure: see text] A new class of shape-modified nucleosides is introduced. The purine heterobases of adenosine and guanosine have been split into their imidazole and pyrimidine components, thereby introducing flexibility while retaining the elements n