374111-67-8Relevant academic research and scientific papers
Discovery of novel (1S)-(-)-verbenone derivatives with anti-oxidant and anti-ischemic effects
Ju, Chung,Song, Sumi,Hwang, Sunyoung,Kim, Chorong,Kim, Minkyoung,Gu, Jail,Oh, Yu-Kyoung,Lee, Kyeong,Kwon, Jinsun,Lee, Kiho,Kim, Won-Ki,Choi, Yongseok
supporting information, p. 5421 - 5425 (2013/09/23)
A series of novel (1S)-(-)-verbenone derivatives was synthesized bearing a 4-styryl scaffold. The synthesized compounds were tested for their anti-oxidant, anti-excitotoxic, and anti-ischemic activities. These derivatives significantly reduced oxygen-glucose deprivation-induced neuronal injury and N-methyl-d-aspartic acid-evoked excitotoxicity in cortical neurons. Furthermore, compound 3f was identified as a potent anti-ischemic agent in an in vitro ischemic model, potentially due to the inhibition of N-methyl-d-aspartic acid-evoked excitotoxicity and oxidative/nitrosative stress.
Novel reactivity of SeO2 with 1,3-dienes: Selenophene formation
Nguyen, Truc M.,Guzei, Ilia A.,Lee, Daesung
, p. 6553 - 6556 (2007/10/03)
A novel and efficient method for the synthesis of selenophenes is disclosed. Selenophenes were synthesized in high yields in a single operation from 1,3-dienes containing a carbonyl group at the C-1 position and selenium dioxide. The bidirectional synthesis of selenophenes can also be demonstrated using this method. The selenophene is believed to form via a [4 + 2] cycloaddition between diene and selenium dioxide.
