37418-37-4Relevant academic research and scientific papers
Synthesis, characterization, computational calculation and biological studies of some 2,6-diaryl-1-(prop-2-yn-1-yl)piperidin-4-one oxime derivatives
Sundararajan,Rajaraman,Srinivasan,Velmurugan,Krishnasamy
, p. 108 - 118 (2015)
A new series of 2,6-diaryl-1-(prop-2-yn-1-yl)piperidin-4-one oximes (17-24) were designed and synthesized from 2,6-diarylpiperidin-4-one oximes (9-16) with propargyl bromide. Unambiguous structural elucidation has been carried out by investigating IR, NMR (1H, 13C, 1H-1H COSY and HSQC), mass spectral techniques and theoretical (DFT) calculations. Further, crystal structure of compound 17 was evaluated by single crystal X-ray diffraction analysis. Single crystal X-ray structural analysis of compound 17 evidenced that the configuration about CN double bond is syn to C-5 carbon (E-form). The existence of chair conformation was further confirmed by theoretical DFT calculation. All the synthesized compounds were screened for in vitro antimicrobial activity against a panel of selected bacterial and fungal strains using Ciprofloxacin and Ketoconazole as standards. The minimum inhibition concentration (MIC) results revealed that most of the 2,6-diaryl-1-(prop-2-yn-1-yl)piperidin-4-one oximes (17, 19, 20 and 23) exhibited better activity against the selected bacterial and fungal strains.
A study on the reactivity of 3-methyl-2,6-diphenyl-4-piperidone
Bhaskar Reddy,Somasekhar Reddy,Padmavathi
, p. 141 - 147 (2007/10/03)
The reactivity of 3-methyl-cis-2,6-diphenyl-4-piperidone 1 has been explored to develop a variety of heterocyclic compounds viz., diazepinone 3, oxazepinone 4, thiadiazole 8, γ-carboline 13, isoxazolyl and pyrazolyl tetrahydropyridines 16 and 17 and various spiro heterocycles 18,19 and 21 by the functionalization of carbonyl and active methylene centres.
