37428-88-9

Upstream product

• 503-87-7 2-thiohydantoin 
• 104-88-1 4-chlorobenzaldehyde 
• 2286-35-3 ethyl 3-(4-chlorophenyl)-2-cyanoacrylate 

Downstream Products

• 120697-22-5 5-(p-chlorobenzylidene)hydantoin 
• 99070-48-1 4-chloro-N-formyl-phenylalanine amide 
• 128256-92-8 3-{4-[1-(4-Chloro-phenyl)-meth-(Z)-ylidene]-5-oxo-4,5-dihydro-1H-imidazol-2-ylsulfanyl}-pentane-2,4-dione 
• 89990-74-9 5-(p-chlorobenzylidene)-2-(benzoylmethylthio)-2-imidazolin-4-one 
• 128256-80-4 5-[1-(4-Chloro-phenyl)-meth-(Z)-ylidene]-3-[(methyl-phenyl-amino)-methyl]-2-thioxo-imidazolidin-4-one 
• 14719-87-0 5-(4-chloro-benzylidene)-2-methylsulfanyl-3,5-dihydro-imidazol-4-one 
• 911371-75-0 2-{4-[1-(4-Chloro-phenyl)-meth-(Z)-ylidene]-5-oxo-4,5-dihydro-1H-imidazol-2-ylsulfanyl}-3-oxo-butyric acid ethyl ester 
• 129228-63-3 6-[1-(4-Chloro-phenyl)-meth-(Z)-ylidene]-2,3-dihydro-6H-imidazo[2,1-b]thiazol-5-one 
• 10040-86-5 5-(4-chlorobenzylidene)hydantoin 

Relevant academic research and scientific papers

Design and Synthesis of Novel Phenylpiperazine Derivatives as Potential Anticonvulsant Agents

Eighteen new 5-benzylidene-3-(4-arylpiperazin-1-ylmethyl)-2-thioxo-imidazolidin-4-ones were designed as hybrid structures from previously reported anticonvulsant compounds, synthesized and tested for anticonvulsant activity. Initial anticonvulsant screeni

A novel way of synthesis of 1,3,5-trisubstituted-2-thioxoimidazolidinones

Title compounds were prepared by 1,4-nucleophilic addition of 2-thioxoimidazolidin-4-ones to 3-aryl-2-cyano acrylates, followed by alkylation. Reaction yield are much better than those obtained in case of Knoevenagel-type condensation.

Glycine derivatives of imidazolones as potential ligands of glycine binding site of NMDA receptors. Part 1

The series of glycine derivatives of diphenyl or (un)substituted arylidene imidazolones was designed and obtained as potential ligands of the glycine binding site of NMDA receptors. The compounds were evaluated in vitro for their affinity to the glycine b