37428-89-0Relevant academic research and scientific papers
Design and Synthesis of Novel Phenylpiperazine Derivatives as Potential Anticonvulsant Agents
Habib, Monica M. W.,Abdelfattah, Mohamed A. O.,Abadi, Ashraf H.
, p. 868 - 874 (2015)
Eighteen new 5-benzylidene-3-(4-arylpiperazin-1-ylmethyl)-2-thioxo-imidazolidin-4-ones were designed as hybrid structures from previously reported anticonvulsant compounds, synthesized and tested for anticonvulsant activity. Initial anticonvulsant screeni
Bicyclic imidazole-4-one derivatives: A new class of antagonists for the orphan G protein-coupled receptors GPR18 and GPR55
Rempel,Atzler,Behrenswerth,Karcz,Schoeder,Hinz,Kaleta,Thimm,Kiec-Kononowicz,Müller
, p. 632 - 649 (2014/05/06)
GPR18 and GPR55 are orphan G protein-coupled receptors (GPCRs) that interact with certain cannabinoid (CB) receptor ligands. In the present study bicyclic imidazole-4-one derivatives were discovered as new scaffolds for the development of antagonists for
Synthesis and anti-inflammatory activity of some new N and S-alkylated arylidene-thioxo-imidazolidinones
Santos,Mourao,Uchoa,Silva,Malta,Moura,Lima,Galdino,Pitta,Barbe
, p. 433 - 440 (2007/10/03)
New arylidene-thioxo-imidazolidinones and S-alkylated arylidene- imidazolidinone derivatives were prepared from substituted 2-thioxo- imidazolidin-4-one by nucleophilic addition of cyanoacrylates. N and S-alkylation was achieved treating 5-arylidene-2-thi
Glycine derivatives of imidazolones as potential ligands of glycine binding site of NMDA receptors. Part 1
Kiec-Kononowicz, Katarzyna,Karolak-Wojciechowska, Janina,Handzlik, Jadwiga
, p. 381 - 388 (2007/10/03)
The series of glycine derivatives of diphenyl or (un)substituted arylidene imidazolones was designed and obtained as potential ligands of the glycine binding site of NMDA receptors. The compounds were evaluated in vitro for their affinity to the glycine b
