37443-73-5

Usage

Uses

Used in Pharmaceutical Research:
HEPE is used as a reagent in organic synthesis and pharmaceutical research, serving as a valuable starting material for the production of potential drug candidates and other valuable chemical compounds.
Used in Agrochemical Development:
HEPE is also utilized in the development of agrochemicals, where its unique structural properties contribute to the creation of effective and innovative products for the agricultural industry.

InChI:InChI=1/C9H17NO3/c11-6-5-10-3-1-9(2-4-10)12-7-8-13-9/h11H,1-8H2

Upstream product

• 177-11-7 4,4-ethylenedioxy-piperidine 
• 107-07-3 2-chloro-ethanol 
• 540-51-2 2-bromoethanol 

Downstream Products

• 1415809-81-2 4-[2-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)ethoxy]phthalonitrile 

Relevant academic research and scientific papers

3,5-Bis(Arylidene)-4-Piperidones Modified by Bisphosphonate Groups as Novel Anticancer Agents

Synthetic approaches for conjugating 3,5-bis(arylidene)-4-piperidones with bisphosphonate moiety were elaborated. These approaches are based either on reaction of Grignard reagent containing dioxolane protected 4-piperidone with tetraethyl ethylidenbisphosphonate followed by crotonic condensation with aromatic aldehydes or on Cu(i) catalyzed 1,3-cycloaddition of tetraethyl but-3-yne-1,1-diylbisphosphonate to N-(2-azidoethyl)-3,5-bis(arylidene)-4-piperidones resulting in corresponding 1,2,3-triazole derivatives. Cytotoxic activity of the synthesized conjugates was dependent on the length of linker connecting piperidone nitrogen atom and bisphosphonate residue. Triazole derivatives of 3,5-bis(arylidene)-4-piperidone series displayed moderate in vitro inhibitory properties towards HCT116 and MCF7 human cancer cell lines with IC50 values in the range of 5.0-7.5 M, whereas conjugates with butylene linker between piperidone nitrogen atom and bisphosphonate moiety were significantly less active.

3,5-Bis(arylidene)-4-piperidinones modified with bisphosphonate groups using a 1,2,3-triazole ring: Synthesis and antitumor properties

An approach to the synthesis of new conjugates of 3,5-bis(arylidene)-4-piperidone pharmacophore with bisphosphonate moiety using a 1,2,3-triazole ring as a linker has been developed. The approach is based on a Cu(I)-catalyzed reaction of tetraethyl (but-3

NOVEL THIENOPYRIMIDINE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention relates to a novel thienopyrimidine derivative having an excellent anti? inflammatory and anti-cancer activity, or a pharmaceutically acceptable salt thereof, a process for the preparation thereof and a pharmaceutical composition comprising the same. The compound according to the present invention strongly inhibits IKB kinase-β (IKK-β) involved in the activation of a transcriptional factor, NF-κB, which is associated with inducing various immune and inflammatory diseases, whereby a composition comprising the compound is a useful therapeutic agent against inflammatory diseases, in particular, arthritis and cancer.

Estrogen receptor ligands. Part 8: Dihydrobenzoxathiin SERAMs with heteroatom-substituted side chains

A series of benzoxathiin SERAMs with heteroatom-substituted amine side chains was prepared. Minor modifications in the side chain resulted in significant effects on biological activity, especially in uterine tissue.