374538-01-9 Usage
Uses
Used in Suzuki Reaction:
4-Fluoro-3-formylphenylboronic acid is used as a reactant in the Suzuki reaction, a widely employed cross-coupling reaction for the formation of carbon-carbon bonds. This reaction is particularly useful for the synthesis of biaryl compounds, which are important structural motifs in pharmaceuticals, agrochemicals, and materials science.
Used in the Preparation of Arylmethylpyrrolidinylmethanols and Amine Derivatives:
4-Fluoro-3-formylphenylboronic acid is used as a starting material for the preparation of arylmethylpyrrolidinylmethanols and amine derivatives. This is achieved through a reaction with MIDA (N-methyliminodiacetic acid), followed by a Suzuki reaction with halides or amination with amines. These derivatives have potential applications in the development of pharmaceutical agents and other organic compounds.
Used in the Preparation of N-(biarylsulfonyl) α-amino acids as MMP-12 Inhibitors:
4-Fluoro-3-formylphenylboronic acid is utilized in the synthesis of N-(biarylsulfonyl) α-amino acids, which serve as matrix metalloproteinase-12 (MMP-12) inhibitors. MMP-12 is an enzyme implicated in various pathological conditions, including chronic obstructive pulmonary disease (COPD) and cancer. The development of MMP-12 inhibitors is an active area of research for potential therapeutic applications.
Used in the Preparation of Para-substituted Formylarylboronic Esters:
4-Fluoro-3-formylphenylboronic acid is used in the synthesis of para-substituted formylarylboronic esters, which are valuable intermediates for regioselective Suzuki-Miyaura cross-coupling with bromobenzene. This allows for the selective formation of specific biaryl compounds, which are important for the development of new pharmaceuticals and other organic materials.
Check Digit Verification of cas no
The CAS Registry Mumber 374538-01-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,7,4,5,3 and 8 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 374538-01:
(8*3)+(7*7)+(6*4)+(5*5)+(4*3)+(3*8)+(2*0)+(1*1)=159
159 % 10 = 9
So 374538-01-9 is a valid CAS Registry Number.
InChI:InChI=1/C7H6BFO3/c9-7-2-1-6(8(11)12)3-5(7)4-10/h1-4,11-12H
374538-01-9Relevant academic research and scientific papers
Use of lithium N,O-dimethylhydroxylamide as an efficient in situ protecting agent for aromatic aldehydes
Roschangar, Frank,Brown, Jennifer C,Cooley Jr., Bobby E,Sharp, Matthew J,Matsuoka, Richard T
, p. 1657 - 1666 (2007/10/03)
The use of lithium N,O-dimethylhydroxylamide as an alternative in situ protecting agent for aryl aldehydes with low ortho-directing properties has been evaluated and subsequently applied to two practical multi-step one-pot syntheses of developmental drug
