37456-44-3

Upstream product

• 37456-51-2 2-<2'-phenyl-2'-oxoethyl>-5,5-dimethyl-1,3-cyclohexanedione 
• 126-81-8 dimedone 
• 70-11-1 α-bromoacetophenone 
• 98-86-2 acetophenone 
• 873-95-0 1-amino-5,5-dimethylcyclohexen-3-one 
• 3282-32-4 2-diazo-acetophenone 

Relevant academic research and scientific papers

Green multicomponent reaction for synthesis of trisubstituted pyrroles in ionic liquid [bmim]BF4

2,4,5-Trisubstituted pyrrole derivatives were efficiently synthesized by one-pot condensation of 1,3-diones, α-bromoacetophenones, and ammonium acetate in ionic liquid [bmim]BF4. The new synthetic method offers multisubstituted pyrroles with th

Microwave-assisted facile synthesis of trisubstituted pyrrole derivatives

We report efficient synthesis of pyrrole derivatives by use of microwave irradiation. Quantitative yields were obtained in short reaction times. Low yields of product were obtained from alicyclic amino unsaturated ketone derivatives; higher yields were ob

De novo design of non-coordinating indolones as potential inhibitors for lanosterol 14-α-demethylase (CYP51)

The development of antifungal drugs that inhibit lanosterol 14-α-demethylase (CYP51) via non-covalent ligand interactions is a strategy that is gaining importance. A series of novel tetraindol-4-one derivatives with 1- and 2-(2,4-substituted phenyl) side chains were designed and synthesized based on the structure of CYP51 and fluconazole. The antifungal activities of these derivatives against eight human pathogenic filamentous fungi and yeast strains were evaluated in vitro by measuring the minimal inhibitory concentrations. Nearly all tested compounds 8a-g displayed activity against Candida tropicalis, Candida guilliermondii and Candida parapsilosis with a minimum inhibitory concentration (MIC) value until 8 μg mL-1, on the other hand compounds 7a-g showed activity against Aspergillus fumigatus with a MIC value of 31.25 μg mL-1. A molecular modeling study of the binding interactions between compounds 6, 7d, 8g and the active site of MtCYP51 was conducted based on the computational docking results.

Cu(OTf)2-catalyzed synthesis of 2,3-disubstituted indoles and 2,4,5-trisubstituted pyrroles from α-diazoketones

A novel method has been devised for the synthesis of 2,4,5-trisubstituted pyrrole derivatives through the coupling of α-diazoketones with β-enaminoketones and esters using 10 mol % of Cu(OTf)2. A wide range of 2,3-disubstituted indole derivatives were also prepared from α-diazoketones and 2-aminoaryl or alkyl ketones. The synthetic versatility of this approach has been exemplified in the formal synthesis of homofascaplysin C.

THE SYNTHESIS AND CHEMISTRY OF AZOLENINES. PART 15. THE MECHANISM OF THE 3-ACYL-2-HYDROXY-3,4-DIHYDRO-2H-PYRROLE TO 1-ACYL-1H-PYRROLE REARRANGEMENT

The conversion of 2,5,5-trimethyl-2-phenacylcyclohexane-1,3-dione (1) into 1,7,7-trimethyl-3-phenyl-7,8-dihydroindolizin-5(6H)-one (3) on heating with ammonium acetate and acetic acid, is shown by studies on model compounds to proceed via two -sigmat