37458-38-1Relevant academic research and scientific papers
Novel and versatile methodology for synthesis of cyclic imides and evaluation of their cytotoxic, DNA binding, apoptotic inducing activities and molecular modeling study
Abdel-Aziz, Alaa A.-M.
, p. 614 - 626 (2008/02/10)
Versatile method has been developed for synthesis of N-substituted imides. Thus, acid anhydrides, imides and dicarboxylic acids were successfully subjected to dehydrative cyclization with substituted amines using DPPOx and Et3N to afford N-substituted imides under mild conditions. The DNA binding and apoptosis induction were investigated with regard to their potential utility as cytotoxic agents. Molecular modeling methods are used to study the cytotoxic activity of the active compounds by means of molecular and quantum mechanics.
Improved synthesis of N-substituted 2,3-pyridine-dicarboximides with microwave irradiation
Blanco, Maria M.,Levin, Gustavo J.,Schapira, Celia B.,Perillo, Isabel A.
, p. 1881 - 1890 (2007/10/03)
The microwave-induced synthesis of N-substituted 2,3- pyridinedicarboximides (1) by means of two different approaches is presented. One involves direct N-alkylation of quinolinimide (2) (Method A) and the other, dehydrative condensation of quinolinic anhydride (4) and amines (Method B). Reactions resulted highly accelerated, with improved yields in relation to those obtained by conventional heating. The scope and limitations of each method and its variants are discussed.
New synthesis of pyrido[2,3-d] and [3,2-d]oxazines
Fahmy, Amin F.,Sauer, Juergen,Youssef, Mohamed Salah K.,Halim, Mohamed Said Abdel,Hassan, Mamdouh A.
, p. 2871 - 2886 (2007/10/03)
N-Hydroxyquinolinimide 1 reacts with each of aromatic arnines, hydrazine hydrate and aromatic hydrocarbons to give arylcarbamoyl pyridines 2, pyrrolopyridines 3, pyridopyridazines 4 and pyridooxazinones 5 and 6. The heterocycles 5 and 6 can be transformed
