374633-46-2

Upstream product

• 76972-10-6 2-chloro-5-(3,4-dimethoxyphenyl)pyrimidine 
• 120908-70-5 1-(3,4-methylenedioxyphenyl)-2,3,4,9-tetrahydro-1H-β-carboline 
• 61-54-1 tryptamine 
• 120-57-0 piperonal 
• 70498-78-1 2-(3,4-dimethoxy-phenyl)-malonaldehyde 
• 33266-39-6 5-(3,4-dimethoxy-phenyl)-1-methyl-1H-pyrimidin-2-one 

Downstream Products

• 374633-47-3 1-(3,4-Methylenedioxyphenyl)-2-[5-(3,4-dimethoxyphenyl)pyrimidin-2-yl]-9-dimethylaminoethyl-2,3,4-trihydro-1H-β-carboline 
• 374926-75-7 1,2,3,4-Tetrahydro-2-[5-(3,4-dimethoxyphenyl)-pyrimidin-2-yl]-3-(3,4-methylenedioxyphenyl)-9H-pyrrolo-[3,4-b]quinolin-9-one 

Relevant academic research and scientific papers

BETA-CARBOLINE DERIVATIVES USEFUL AS INHIBITORS OF PHOSPHODIESTERASE

The present invention relates to novel beta-carboline derivatives of the general formulawherein all the variables are as described within the specification, useful as phosphodiesterase inhibitors. The present invention further relates to use of the described derivatives for the treatment of diseases and conditions related to PDE, for example male erectile dysfunction.

Synthesis and biological activities of novel β-carbolines as PDE5 inhibitors

A series of N2-furoyl and N2pyrimidinyl β-carbolines was discovered to possess potent inhibitory activity against PDE5. During the synthesis we developed a tandem resin quenching protocol, which allowed us to synthesize large number

SUBSTITUTED PYRROLOPYRIDINONE DERIVATIVES USEFUL AS PHOSPHODIESTERASE INHIBITORS

The invention relates to novel pyrrolopyridinone derivatives of the formula (I) or (II): pharmaceutical compositions containing the compounds and their use for the treatment of sexual dysfunction

Pyrimidinylpyrroloquinolones as highly potent and selective PDE5 inhibitors for treatment of erectile dysfunction

A series of N-pyrimidinylpyrroloquinolones were discovered as extremely potent and selective PDE5 inhibitors. Representative compounds demonstrated in vivo efficacy in dog erectile dysfunction models and are orally bioavailable.

BETA-CARBOLINE DERIVATIVES USEFUL AS INHIBITORS OF PHOSPHODIESTERASE

The present invention relates to novel beta-carboline derivatives of the general formula wherein all the variables are as described within the specification, useful as phosphodiesterase inhibitors. The present invention further relates to use of the descr