37464-79-2Relevant academic research and scientific papers
Acid-catalyzed reduction of ketones by an NADH model compound and the relation with acid-catalyzed photoinduced electron-transfer reactions
Fukuzumi, Shunichi,Chiba, Makoto,Tanaka, Toshio
, p. 31 - 34 (1989)
Various ketones are readily reduced by an acid-stable NADH model compound, 10-methylacridan (AcrH2), in the presence of perchloric acid in acetonitrile.Rates of the acid-catalyzed reduction of ketones by unprotonated AcrH2 are well correlated with rates of the acid-catalyzed photoinduced electron-transfer reactions from the excited state of 2+ to the ketones.
Practical Method for Reductive Deuteration of Ketones with Magnesium and D2O
Bao, Hongli,Li, Yajun,Su, Min,Wan, Wen-Ming,Zhu, Nengbo
supporting information, (2020/02/15)
α-Deuterated alcohols have important applications in pharmaceuticals and mechanism studies. Here, we report a new and practical strategy for the reductive deuteration of ketones using a Mg/BrCH2CH2Br/D2O system, which affords α-deuterated alcohols in good yields and with almost quantitative incorporation of deuterium. The synthetic value of this method has been demonstrated by the easy access to deuterated drugs or drug derivatives. This method may inspire the discovery of other deuterium-containing drugs.
