37470-58-9

Usage

Uses

Used in Organic Synthesis:
ETHYL 3-BROMO-4-HYDROXYBENZOATE is used as an intermediate in the synthesis of more complex chemical compounds. Its unique structure with bromo and hydroxy substituents on the phenyl ring, along with the ester functional group, makes it a valuable component in the creation of various organic molecules. This application is crucial in the development of new pharmaceuticals, agrochemicals, and other specialty chemicals.

Upstream product

• 120-47-8 Ethyl 4-hydroxybenzoate 
• 64-17-5 ethanol 
• 14348-41-5 3-bromo-4-hydroxy-benzoic acid 
• 17348-65-1 di(methyl)tert-butyl(ethoxy)silane 
• 123-08-0 4-hydroxy-benzaldehyde 

Downstream Products

• 875846-74-5 3-bromo-4-butoxy-benzoic acid ethyl ester 
• 875846-59-6 3-Brom-4-ethoxy-ethyl-benzoat 
• 92104-99-9 3-Bromo-4-(2-dimethylamino-ethoxy)-benzoic acid ethyl ester 
• 251477-23-3 ethyl 2-bromo-6-iodo-4-hydroxybenzoate 

Relevant academic research and scientific papers

THERAPEUTIC AGENT FOR INFLAMMATORY DISEASES, AUTOIMMUNE DISEASES, FIBROTIC DISEASES, AND CANCER DISEASES

A therapeutic agent for treating at least one disease selected from the group consisting of inflammatory diseases, autoimmune diseases, fibrotic diseases, and cancer diseases, comprising: at least one selected from the group consisting of a compound represented by the following general formula (1) and pharmacologically acceptable salts thereof as an active ingredient. [In the formula (1), R1 and R2 may be the same or different and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a carboxy group, a cyano group, an optionally substituted C1-6 alkyl group et al.; R3 represents a hydrogen atom; R4 represents an optionally substituted 4- to 10-membered monocyclic heterocyclic group containing 1 to 4 heteroatoms selected from an oxygen atom, a nitrogen atom, and a sulfur atom; X represents a group represented by the following formula: -CH2-, - CH2-CH2-, -CH2-CH2-CH2-, or -CH2-O-CH2-; and Z represents a hydrogen atom or a hydroxyl group.]

Single-Step Dual Functionalization: One-Pot Bromination-Cross-Dehydrogenative Esterification of Hydroxy Benzaldehydes with CCl 3 Br - A Comparison with Selectfluor

Bromination of phenolic compounds without directly using molecular bromine possesses much importance. In this article an Ir III /CCl 3 Br-assisted single-step double functionalization of hydroxy benzaldehydes is reported. It involves simultaneous esterification of the aldehyde group and bromination of the aryl ring of phenolic aldehydes in one-pot. The reaction proceeds under mild conditions in the presence of 445 nm blue LED light to obtain highly functionalized bromo hydroxy benzoates in moderate to good yields. In comparison, Selectfluor as an oxidant gives only non-bromo phenolic esters.

NOVEL COMPOUND AND PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF

A compound represented by the general formula (1) below or a pharmacologically acceptable salt thereof: [In the formula (1), R1 and R2 may be the same or different and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a carboxy group, a cyano group, an optionally substituted C1-6 alkyl group et al.; R3 represents a hydrogen atom; R4 represents an optionally substituted 4- to 10-membered monocyclic heterocyclic group containing 1 to 4 heteroatoms selected from an oxygen atom, a nitrogen atom, and a sulfur atom; X represents a group represented by the following formula: —CH2—, —CH2—CH2—, —CH2—CH2—CH2—, or —CH2—O—CH2—; and Z represents a hydrogen atom or a hydroxyl group.]

Convenient synthesis of functionalized terphenyls

A convenient synthetic methodology amenable for rapid synthesis of differentially functionalized terphenyls is described. Orthogonality requirements for the incorporation of phenoxy acetic acid and carboxamide function have been satisfied by utilization o