203662-51-5

Basic information

• Product Name: 4-Hydroxy-4-(2-propenyl)piperidine-1-carboxylic acid tert-butyl ester
• Synonyms: 4-Hydroxy-4-(2-propenyl)piperidine-1-carboxylic acid tert-butyl ester;tert-butyl 4-allyl-4-hydroxypiperidine-1-carboxylate;1-Piperidinecarboxylic acid, 4-hydroxy-4-(2-propen-1-yl)-, 1,1-diMethylethyl ester;1-Piperidinecarboxylic acid, 4-hydroxy-4-(2-propenyl)-, 1,1-diMethylethyl ester;4-Allyl-1-Boc-4-hydroxypiperidine;1-Boc-4-allyl-4-hydroxypiperidine;tert-butyl 4-hydroxy-4-(prop-2-en-1-yl)piperidine-1-carboxylate
• CAS NO: 203662-51-5
• Molecular Formula: C₁₃H₂₃NO₃
• Molecular Weight: 241.33
• Product Categories: pharmacetical
• Mol File: 203662-51-5.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 318.135 °C at 760 mmHg
• Flash Point: 146.203 °C
• Appearance: /
• Density: 1.052
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.493
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-Hydroxy-4-(2-propenyl)piperidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hydroxy-4-(2-propenyl)piperidine-1-carboxylic acid tert-butyl ester(203662-51-5)
• EPA Substance Registry System: 4-Hydroxy-4-(2-propenyl)piperidine-1-carboxylic acid tert-butyl ester(203662-51-5)

Safety Data

• RIDADR: UN2811
• Hazardous Substances Data: 203662-51-5(Hazardous Substances Data)

Usage

General Description

4-Hydroxy-4-(2-propenyl)piperidine-1-carboxylic acid tert-butyl ester is a chemical compound that is commonly used as an intermediate in the synthesis of pharmaceuticals. It is an ester derivative of 4-hydroxy-4-(2-propenyl)piperidine-1-carboxylic acid, containing a tert-butyl ester group. 4-Hydroxy-4-(2-propenyl)piperidine-1-carboxylic acid tert-butyl ester possesses significant biological activity and has been studied for its potential therapeutic applications in the treatment of various diseases. It is also utilized in research and development of new drugs and chemical compounds. Additionally, 4-Hydroxy-4-(2-propenyl)piperidine-1-carboxylic acid tert-butyl ester is a valuable reagent in organic synthesis, providing a versatile building block for the preparation of different types of molecules. Overall, this compound is a key component in the pharmaceutical and chemical industries, with numerous potential uses and applications.

InChI:InChI=1/C13H23NO3/c1-5-6-13(16)7-9-14(10-8-13)11(15)17-12(2,3)4/h5,16H,1,6-10H2,2-4H3

Upstream product

• 10049-21-5 sodium dihydrogenphosphate 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 1730-25-2 allylmagnesium bromide 
• 106-95-6 allyl bromide 
• 463-49-0 1,2-propanediene 

Downstream Products

• 240401-09-6 tert-butyl 3-hydroxy-1-oxa-8-azaspiro[ 4.5]decane-8-carboxylate 
• 1346229-46-6 tert-butyl 3-oxo-1-oxa-9-azaspiro[5.5]undecane-9-carboxylate 
• 374795-40-1 tert-butyl 1-oxa-9-azaspiro[5.5]undec-3-ene-9-carboxylate 
• 374795-42-3 tert-butyl 3-hydroxy-1-oxa-9-azaspiro[5.5]undecane-9-carboxylate 
• 374795-39-8 tert-butyl 4-allyl-4-(allyloxy)piperidine-1-carboxylate 
• 1160246-91-2 tert-butyl 3-amino-1-oxa-8-azaspiro[4.5]decane-8-carboxylate 
• 1346229-51-3 tert-butyl 4-oxo-1-oxa-9-azaspiro[5.5]undecane-9-carboxylate 
• 374796-29-9 tert-butyl 4-hydroxy-1-oxa-9-azaspiro[5.5]undecane-9-carboxylate 
• 1227472-26-5 tert-butyl 3-[3-(trifluoromethoxy)phenyl]-1-oxa-8-azaspiro[4.5]decane-8-carboxylate 

Relevant articles and documents

Nitroimidazole compound as well as preparation method and application thereof

The invention discloses a novel nitroimidazole compound as well as a preparation method and application thereof. The nitroimidazole compound has a general formula (I) shown in the specification.

Catalytic Regioselective Olefin Hydroarylation(alkenylation) by Sequential Carbonickelation-Hydride Transfer

Alkene hydrocarbofunctionalization represents one of the most important classes of chemical transformations, but related branched-selective examples with unactivated olefins are scarce. Here, we report that catalytic amounts of a dimeric Ni(I) complex and an exogenous alkoxide base promote Markovnikov-selective hydroarylation(alkenylation) of unactivated and activated olefins using organo bromides or triflates derived from widely available phenols and ketones. Products bearing aryl- and alkenyl-substituted tertiary and quaternary centers could be isolated in up to 95% yield and >99:1 regioisomeric ratios. Contrary to previous dual-catalytic methods that rely on metal-hydride atom transfer (MHAT) to the olefin prior to carbofunctionalization with a cocatalyst, our mechanistic evidence points toward a nonradical reaction pathway that begins with site-selective carbonickelation across the C═C bond followed by hydride transfer using alkoxide as the hydride source. Utility of the single-catalyst protocol is highlighted through the synthesis of medicinally relevant scaffolds.

Enantioselective Allylation Using Allene, a Petroleum Cracking Byproduct

Allene (C3H4) gas is produced and separated on million-metric-ton scale per year during petroleum refining but is rarely employed in organic synthesis. Meanwhile, the addition of an allyl group (C3H5) to ketones is among the most common and prototypical reactions in synthetic chemistry. Herein, we report that the combination of allene gas with inexpensive and environmentally benign hydrosilanes, such as PMHS, can serve as a replacement for stoichiometric quantities of allylmetal reagents, which are required in most enantioselective ketone allylation reactions. This process is catalyzed by copper salts and commercially available ligands, operates without specialized equipment or pressurization, and tolerates a broad range of functional groups. Furthermore, the exceptional chemoselectivity of this catalyst system enables industrially relevant C3 hydrocarbon mixtures of allene with methylacetylene and propylene to be applied directly.