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3752-24-7

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3752-24-7 Usage

Uses

4,5-Tetramethyleneimidazole is a useful reactant for preparation of imidazolylnitroquinoxalinedione.

Synthesis Reference(s)

The Journal of Organic Chemistry, 41, p. 19, 1976 DOI: 10.1021/jo00863a004

Check Digit Verification of cas no

The CAS Registry Mumber 3752-24-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,7,5 and 2 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 3752-24:
(6*3)+(5*7)+(4*5)+(3*2)+(2*2)+(1*4)=87
87 % 10 = 7
So 3752-24-7 is a valid CAS Registry Number.
InChI:InChI=1/C7H10N2/c1-2-4-7-6(3-1)8-5-9-7/h5H,1-4H2,(H,8,9)

3752-24-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 4,5,6,7-Tetrahydro-1H-benzo[d]imidazole

1.2 Other means of identification

Product number -
Other names 4,5,6,7-tetrahydro-1H-benzimidazole

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:3752-24-7 SDS

3752-24-7Relevant articles and documents

Rational Design, Synthesis and Evaluation of Novel C6-Bicycloalkaneimidazole Containing Imidazo[1,2-b]pyridazines for ASK1 Inhibition

Lee, Yujin,Jang, Jiyoon,Bibi, Maimoona,Duggirala, Krishna Babu,Ji, Sang Hee,Lee, Ji Hun,Ahn, Sunjoo,Song, Jin Sook,Chae, Chong Hak,Kim, Seong Hwan,Lee, Kwangho

, p. 872 - 877 (2021/05/10)

Apoptosis signal-regulating kinase 1 (ASK1) is a member of mitogen-activated protein kinase kinase kinase (MAP3K) family that involves downstream phosphorylation of MAP kinases, c-Jun N-terminal kinases, and p38 MAP kinases. ASK1 inhibitors could possibly be beneficial for ameliorating the development and progression of diseases. Especially, ASK1 has been of interest as one of therapeutic targets for nonalcoholic fatty liver disease as the most common chronic liver diseases including simple steatosis and nonalcoholic steatohepatitis. In this manuscript, novel ASK1 inhibitor lead KTA-29 which has an imidazo[1,2-b]pyridazine core with novel C6-bicycloheptaneimidazole is disclosed. With the novel imidazo[1,2-b]pyridazine core, structure-activity-relationship study for ASK1 potency is described and KTA-29 affinity toward ASK1 with molecular modeling study is explained.

TETRAHYDROBENZIMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY

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Page/Page column 87; 88, (2015/06/25)

A series of substituted 4,5,6,7-tetrahydrobenzimidazole derivatives, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders;

Biaryl derived amide modulators of vanilloid VR1 receptor

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Page/Page column 42, (2010/11/24)

The invention is directed to novel vanilloid receptor type 1 (VR1) ligands. More specifically, the invention relates to novel biaryl-derived amides that are potent antagonists or agonists of VR1. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.

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