3752-57-6

Upstream product

• 122-04-3 4-nitro-benzoyl chloride 
• 75443-90-2 8-formyl-des-AB-cholest-8-ene 
• 75415-64-4 Benzoic acid (1R,3aS,4R,7aR)-1-((R)-1,5-dimethyl-hexyl)-5-hydroxy-7a-methyl-octahydro-inden-4-ylmethyl ester 
• 75415-64-4 8α-benzoyloxymethyl-9β-hydroxy-des-AB-cholestane 
• 75415-62-2 C₄₂H₅₈O₅ 
• 75444-72-3 Benzoic acid (1R,3aS,4R,5S,7aR)-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-5-(toluene-4-sulfonyloxy)-octahydro-inden-4-ylmethyl ester 
• 75423-12-0 9β-toluene-p-sulphonyloxy-8α-formyl-des-AB-cholestane 
• 75415-60-0 Acetic acid (3S,5R,8S,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-3-methoxy-5,13-dimethyl-6-oxo-2,3,4,5,6,7,8,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-7-yl ester 
• 75415-67-7 Benzoic acid (1R,3aS,4R,5R,7aR)-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-5-phenylsulfanyl-octahydro-inden-4-ylmethyl ester 
• 75423-13-1 Toluene-4-sulfonic acid (1R,3aS,4R,5S,7aR)-1-((R)-1,5-dimethyl-hexyl)-4-hydroxymethyl-7a-methyl-octahydro-inden-5-yl ester 
• 75415-68-8 (1R,3aS,4R,5R,7aR)-5-Benzenesulfonyl-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-octahydro-indene-4-carbaldehyde 
• 75415-59-7 3β-methoxy-5β-methyl-6-trimethylsilyloxy-19-norcholesta-6,9-diene 
• 75415-66-6 9α-phenylsulphonyl-8α-hydroxymethyl-des-AB-cholestane 
• 5226-32-4 6β-acetoxy-3β-methoxy-5β-methyl-19-norcholest-9-ene 

Downstream Products

• 74055-38-2 Benzoic acid 1-[(3S,5R)-3,5-bis-(tert-butyl-dimethyl-silanyloxy)-2-methyl-cyclohex-1-enyl]-2-[(1R,3aR,7aR)-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-yl]-2-(toluene-4-sulfonyl)-ethyl ester 
• 75212-01-0 3β,6-dibenzoyloxy-7-p-tolylsulphonyl-9,10-seco-cholesta-5(10),8-diene 
• 74055-39-3 (3R,3aR,7aR)-7-{(E)-2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methyl-cyclohex-1-enyl]-vinyl}-3-((R)-1,5-dimethyl-hexyl)-3a-methyl-2,3,3a,4,5,7a-hexahydro-1H-indene 
• 108887-35-0 1α,3β-bis(tert-butyldimethylsilyloxy)-9,10-secocholesta-5,7,10(19)-triene 
• 75211-99-3 8-p-tolylsulphonylmethyl-des-AB-cholest-8-ene 
• 17488-99-2 tachysterol₃ 4-methyl-3,5-dinitrobenzoate 
• 17592-07-3 tachysterol₃ 
• 1173-13-3 previtamin D₃ 
• 41294-56-8 1α-hydroxyvitamin D3 

Relevant academic research and scientific papers

Synthesis of 8-methylene-des-AB-cholestan-9-one by cholesterol degradation

The short synthetic route from 3β-acetoxy-5β-methyl-19-norcholest-9(10)-en-6-one (1) to 8-methylene-des-AB-cholestan-9-one (8) is described.Compound 8 is a convenient intermediate for synthesis of relatives of vitamin D3 by the A CD route.

Calciferol and its Relatives. Part 26. A Conversion of Cholesterol into 8-Hydroxymethyl-des-AB-cholest-8-ene

The methoxy-ketone (7), derived from Westphalen's diol, was degraded to 8α-benzoyloxymethyl-des-AB-cholestan-9-one (10), from which the title compound (6) was obtained in a yield of 47percent based on the ketone (7), or 22.5percent overall from cholestero