37535-51-6

Basic information

• Product Name: 3-(2-Pyridyl)-L-alanine
• Synonyms: L-3-(2-pyridyl)-alanine;3-Pyridin-2-yl-L-alanine;H- Ala(2-pyridyl)-OH·2HCl;3-(2-Pyridyl)-L-Ala-OH;3-(2-PYRIDYL)-ALANINE 99%MIN;(S)-2-Amino-3-(2-pyridyl)propionic acid, 2μ-Aza-L-phenylalanine;L-2-Pal-OH;3-(2-Pyridyl)-L-alanine
• CAS NO: 37535-51-6
• Molecular Formula: C₈H₁₀N₂O₂
• Molecular Weight: 166.18
• Product Categories: Amino Acids;chiral;Unusual Amino Acids;a-amino
• Mol File: 37535-51-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 216-217 °C (decomp)
• Boiling Point: 322.4 °C at 760 mmHg
• Flash Point: 148.8 °C
• Appearance: /Solid
• Density: 1.271 g/cm³
• Vapor Pressure: 0.000116mmHg at 25°C
• Refractive Index: 1.581
• Storage Temp.: Store at 0-5°C
• PKA: 1.73±0.10(Predicted)
• BRN: 6478360
• CAS DataBase Reference: 3-(2-Pyridyl)-L-alanine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-Pyridyl)-L-alanine(37535-51-6)
• EPA Substance Registry System: 3-(2-Pyridyl)-L-alanine(37535-51-6)

Safety Data

• Hazard Codes: Xi
• WGK Germany: 3
• Hazardous Substances Data: 37535-51-6(Hazardous Substances Data)

Usage

General Description

3-(2-Pyridyl)-L-alanine is a chemical compound that is derived from the amino acid L-alanine and has a pyridyl functional group attached to it. This modification gives it unique properties which make it useful in various fields such as pharmaceutical research. 3-(2-Pyridyl)-L-alanine may be synthetically produced, or could potentially occur naturally in certain organisms, but it's not commonly found in most living organisms. It's often used in laboratory settings, typically as part of larger, more complex molecules.

InChI:InChI=1/C8H10N2O2/c9-7(8(11)12)5-6-3-1-2-4-10-6/h1-4,7H,5,9H2,(H,11,12)/t7-/m1/s1

Upstream product

• 74164-26-4 N^α-acetyl-β-(2-pyridyl)-L-alanine 
• 71239-85-5 N-(t-butoxycarbonyl)-3-(pyridin-2-yl)-DL-alanine 
• 185379-37-7 N^α-acetyl-β-(2-pyridyl)-DL-alanine ethyl ester 
• 19814-60-9 diethyl 2-acetamido-2-(methylpyridin-2-yl)malonate 
• 54495-51-1 (E)-3-(2-pyridyl)acrylic acid 

Downstream Products

• 28696-52-8 trans-carboxylate-(Co(L-histidinate)2)(1+) 
• 18744-92-8 trans-imidazole-(Co(L-histidinate)2)(1+) 
• 72982-76-4 trans-carboxylate-(Co(L-β-(2-pyridyl)-α-alaninate))(1+) 
• 72905-42-1 trans-carboxylate-[Co(L-β-(2-pyridyl)-α-alaninate)(L-histidinate)]NO3*H2O*0.25ethanol 
• 72937-78-1 trans-[Co(L-β-(2-pyridyl)-α-alaninate)(L-histidinate)](NO3)*2H2O 
• 24419-71-4 trans-amino-(Co(L-histidinate)2)(1+) 
• 17407-44-2 D,L-β-(2-pyridyl)-α-alanine 
• 71239-85-5 N-(t-butoxycarbonyl)-3-(pyridin-2-yl)-DL-alanine 

Relevant articles and documents

A practical and scalable system for heteroaryl amino acid synthesis

A robust system for the preparation of β-heteroaryl α-amino acid derivatives has been developed using photoredox catalysis. This system operates via regiospecific activation of halogenated pyridines (or other heterocycles) and conjugate addition to dehydroalanine derivatives to deliver a wide range of unnatural amino acids. This process was conducted with good efficiency on large scale, the application of these conditions to amino ketone synthesis is shown, and a simple protocol is given for the preparation of enantioenriched amino acid synthesis, from a number of radical precursors.

Novel preparation of chiral α-amino acids using the Mitsunobu-Tsunoda reaction

An efficient synthesis of racemic or optically active α-amino acids by modified-Mitsunobu alkylation of a racemic or chiral glycine template from alcohols was developed. Libraries of amino acids were prepared in moderate to good yield with good to high enantioselectivity. This simple method widens the scope for preparation of structurally diverse amino acids.

Studies on polypeptides XXXII. Solid-phase synthesis of RNase S-peptide 1-14 analogues; replacement of histidine-12 by β-(2-pyridyl)-L-alanine and β-(4-pyridyl)-L-alanine

The synthesis of two analogues of the N-terminal tetradecapeptide of ribonuclease A (RNase S-peptide 1-14), in which the active site histidine-12 residue is replaced by β-(2-pyridyl)-L-alanine and β-(4-pyridyl)-L-alanine, has been accomplished by the solid-phase method.The enantiomers of β-(2-pyridyl)alanine were obtained by chymotryptic hydrolysis of its racemic Nα-acetyl ethyl ester.The Boc derivative of both L-amino acids has been synthesized.