375369-14-5

Basic information

• Product Name: 6-BROMOBENZOXAZOLE
• Synonyms: 6-BROMOBENZO[D]OXAZOLE;6-BROMOBENZOXAZOLE;6-broMo-1,3-benzoxazole
• CAS NO: 375369-14-5
• Molecular Formula: C₇H₄BrNO
• Molecular Weight: 198.02
• Mol File: 375369-14-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 251.2 °C at 760 mmHg
• Flash Point: 105.7 °C
• Appearance: /
• Density: 1.71 g/cm³
• Storage Temp.: 2-8°C(protect from light)
• PKA: -0.49±0.30(Predicted)
• CAS DataBase Reference: 6-BROMOBENZOXAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BROMOBENZOXAZOLE(375369-14-5)
• EPA Substance Registry System: 6-BROMOBENZOXAZOLE(375369-14-5)

Safety Data

• Hazardous Substances Data: 375369-14-5(Hazardous Substances Data)

Usage

General Description

6-Bromobenzoxazole is a chemical compound with the molecular formula C7H4BrNO, consisting of a benzene ring fused to a oxazole ring with a bromine atom attached at the 6-position. It is a pale yellow to beige crystalline solid that is used in organic synthesis as a building block for various pharmaceuticals and agrochemicals. 6-Bromobenzoxazole is also employed as a fluorescent dye in biological and analytical research, as it emits blue light when exposed to UV radiation. It is considered to be a hazardous chemical and should be handled with care, as it may cause irritation to the skin, eyes, and respiratory system.

Upstream product

• 38191-34-3 2-amino-5-bromophenol 
• 122-51-0 orthoformic acid triethyl ester 
• 149-73-5 trimethyl orthoformate 

Downstream Products

• 954239-67-9 methyl 6-bromobenzo[d]oxazole-2-carboxylate 
• 1638125-48-0 (6-bromobenzo[d]oxazol-2-yl)(phenyl)methanone 
• 1112982-47-4 N-(5-(benzo[d]oxazol-6-yl)-2-chloropyridin-3-yl)-4-fluorobenzenesulfonamide 

Relevant articles and documents

Method for synthesizing benzoxazole through microwave radiation of benzamide compound in water phase

The invention discloses a method for synthesizing benzoxazole through microwave radiation of a benzamide compound in a water phase. The benzamide compound is added into the water phase under the microwave condition to be subjected to a cyclization reaction for generating the benzoxazole under the alkali condition, and the method for preparing the benzoxazole is environmentally friendly, easy and convenient to operate, safe, low in cost and efficient. Compared with the prior art, the method can be applied to a large number of functional groups, the yield is high, the number of by-products is small, and the method is easy to operate, safe, low in cost and environmentally friendly. (Please see the specifications for the formula).

Cobalt-Catalyzed Cross-Dehydrogenative Coupling Reactions of (Benz)oxazoles with Ethers

The cobalt-catalyzed cross-dehydrogenative coupling of (benz)oxazoles and ethers is described. Access to some important bioactive heteroaryl ether derivatives was achieved using CoCO3 as an inexpensive catalyst at levels as low as 1.0 mol %. In