375385-25-4

Upstream product

• 6971-51-3 3-methoxybenzyl alcohol 
• 162136-06-3 (2-iodo-3-methoxyphenyl)methanol 

Downstream Products

• 375385-32-3 6-(2-iodo-3-methoxybenzyl)-3-isobutoxycyclohex-2-en-1-one 
• 1108207-52-8 [4-(2-iodo-3-methoxyphenyl)-1-butynyl](triisopropyl)silane 
• 1131444-93-3 tert-butyl N-benzyl-N-[2-(2-iodo-3-methoxyphenyl)-1-methoxycarbonylethyl]carbamate 
• 1187632-61-6 Br^(1-)*C₃₆H₃₉INO₄⁽¹⁺⁾ 
• 375385-37-8 4-(2-iodo-3-methoxybenzyl)cyclohex-2-en-1-one 
• 914614-05-4 4-(2-iodo-3-methoxybenzyl)-3-methyl-cyclohex-2-enone 
• 875152-62-8 2-(2-iodo-3-methoxy-benzyl)-5-isobutoxy-3-oxo-3,6-dihydro-2H-pyridine-1-carboxylic acid methyl ester 
• 1573172-21-0 C₂₂H₂₂INO 
• 1573171-76-2 (E)-3-benzyl-4-(2-((dibenzylamino)methyl)-6-methoxyphenyl)-1,1,1-trifluorobut-3-en-2-one 
• 1573171-40-0 (E)-4-(2-((dibenzylamino)methyl)-6-methoxyphenyl)-1,1,1-trifluorobut-3-en-2-one 
• 1573171-98-8 2-((dibenzylamino)methyl)-6-methoxybenzaldehyde 

Relevant academic research and scientific papers

NOVEL SELECTIVE KAPPA OPIOID RECEPTOR ANTAGONISTS AND METHODS RELATED THERETO FOR TREATMENT OF ADDICTION AND NEUROPATHIC PAIN

Disclosed is a composition and method for a therapeutic treatment that is able to combat certain conditions such as addiction, alcohol dependence, opioid abuse treatment, neurological disorders, neuropathic pain, and combinations thereof. The compounds act by acting as selective antagonist to the kappa (K) opioid receptor, which, when present leads to the inhibition of conditions, providing increased performance over known treatments. The disclosed compounds also shows the ability to cross the blood-brain-barrier in a highly efficient manner. The disclosed compounds are shown to be effective in the nanomolar range.

Synthesis of methoxy substituted centrally chiral triynes as precursors of functionalised nonracemic helicene-like compounds

A modular synthesis of a series of methoxy substituted optically pure aromatic triynes (-)-(S)-5-9 and (-)-(R)-10 is presented. It relies on key operations such as substitution of benzylic bromine with an alkoxy group and aryl-alkyne coupling reaction to

Intramolecular conjugate addition of alkenyl and aryl functions to enones initiated by lithium-iodine exchange

Equation presented Treatment of each of the substrates 20-26, 29, and 46-48 with t-BuLi in THF, in the presence of HMPA and TMSCI, provides good-to-excellent yields of the intramolecular conjugate addition products 30-36, 37, and 49-51, respectively.