375386-98-4

Upstream product

• 52200-05-2 4-methanesulfonyloxy-3-methoxybenzaldehyde 
• 151-50-8 potassium cyanide 
• 5763-61-1 3,4-dimethoxybenzylamine 

Downstream Products

• 375387-00-1 [4-hydroxy-3-(4-methanesulfonyloxy-3-methoxy-phenyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinolin-4-yl]-acetic acid ethyl ester 
• 773840-70-3 methanesulfonic acid 4-(6,7-dimethoxy-4-oxo-1,2,3,4-tetrahydro-isoquinolin-3-yl)-2-methoxy-phenyl ester 

Relevant academic research and scientific papers

Synthesis, biological activity and comparative analysis of DNA binding affinities and human DNA topoisomerase I inhibitory activities of novel 12-alkoxy-benzo[c]phenanthridinium salts

New antitumor 12-alkoxy-benzo[c]phenanthridinium derivatives were obtained in high yields through multistep syntheses. Analysis of DNA binding and human DNA topoisomerase I inhibitory activities demonstrates that new compounds, combining 2, 6, and 12 substitutions, interact strongly with DNA and exhibit important topoisomerase I inhibition. The cytotoxicities against solid tumor cell lines are also determined and compared with those for fagaronine and ethoxidine.