37545-33-8

Basic information

• Product Name: 5-METHYLPYRAZINE-2-CARBOHYDRAZIDE
• Synonyms: 5-METHYLPYRAZINE-2-CARBOHYDRAZIDE
• CAS NO: 37545-33-8
• Molecular Formula: C₆H₈N₄O
• Molecular Weight: 152.16
• Product Categories: Pyrazines, Pyrimidines & Pyridazines;Pyrazines, Pyrimidines & Pyridazines
• Mol File: 37545-33-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-METHYLPYRAZINE-2-CARBOHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHYLPYRAZINE-2-CARBOHYDRAZIDE(37545-33-8)
• EPA Substance Registry System: 5-METHYLPYRAZINE-2-CARBOHYDRAZIDE(37545-33-8)

Safety Data

• Hazardous Substances Data: 37545-33-8(Hazardous Substances Data)

Usage

General Description

5-Methylpyrazine-2-carbohydrazide is a chemical compound with the molecular formula C5H8N4O. It is a derivative of pyrazine, containing a carbohydrazide group at the 2-position and a methyl group at the 5-position. 5-METHYLPYRAZINE-2-CARBOHYDRAZIDE is used as a building block for the synthesis of various pharmaceuticals, agrochemicals, and organic compounds. It has been studied for its potential as an anticancer agent, and it also exhibits antifungal and antibacterial properties. 5-Methylpyrazine-2-carbohydrazide is a yellow powder that is typically stored in a cool, dry place away from direct sunlight and sources of ignition. It should be handled and disposed of according to proper laboratory safety guidelines and regulations.

Upstream product

• 41110-34-3 5-methyl-2-pyrazine carboxylic acid ethyl ester 
• 5521-55-1 2-methylpyrazin-5-carboxylic acid 

Relevant articles and documents

Synthesis of pyrazine derivatives as potential hypoglycemic agents.

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Pyrazine associated novel 1,2,4-triazolo thiadazines: Synthesis, characterization and as antibacterial agents

5-(5-Methyl-pyrazin-2-yl)-[1,3,4]-oxadiazole-2-thiol (4) has been synthesized form the starting material 5-methyl-2-pyrazinecarboxylic acid (1) on esterification with ethanol and condensation with hydrazine hydrate followed by cyclization with carbon disu

3- (1,2,4-TRIAZOL-3YLALKYL) AZABRICLO (3.1.0) HEXANE DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS

The present invention relates to novel compounds of formula (I) or pharmaceutically acceptable salt thereof: wherein " G is selected from a group consisting of: phenyl, pyridyl, benzothiazolyl and indazolyl; " p is an integer ranging from 0 to 5; " R1 is independently selected from a group consisting of: halogen, hydroxy, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, haloC1-4alkoxy, C1-4alkanoyl and SF5, or corresponds to a group R5; " each R2 is independently hydrogen, fluorine or C1-4alkyl; " n is 2, 3, 4, or 5; " R3 is C1-4alkyl; " R4 is hydrogen, or a C1-4alkyl group, a benzyl group, a phenyl group, a heterocyclyl group, a 5- or 6-membered heteroaromatic group, or a 8- to 11-membered bicyclic group, any of which groups is optionally substituted by 1, 2, 3 or 4 substituents selected from the group consisting of: halogen, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, haloC1-4alkoxy, C1-4alkanoyl and SF5;or R4 is a -SR6 group; " R5 is selected from a group consisting of: isoxazolyl, -CH2-N-pyrrolyl, 1,1-dioxido-2-isothiazolidinyl, thienyl, thiazolyl, pyridyl and 2-pyrrolidinonyl, and such a group is optionally substituted by one or two substituents selected from a group consisting of: halogen, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy and C1-4alkanoyl; " R6 is C1-4alkyl or -CH2C3-4cycloalkyl; and when R1 is chlorine and p is 1, such R1 is not present in the ortho position with respect to the linking bond to the rest of the molecule; and when R1 corresponds to R5, p is 1. processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, as modulators of dopamine D3 receptors, e.g. to treat drug dependency, as antipsychotic agents, to treat obsessive compulsive spectrum disorders, premature ejaculation or cognition impairment.