37548-92-8

Upstream product

• 34052-37-4 2-chloro-5-nitrobenzophenone 
• 100-46-9 benzylamine 
• 102725-61-1 {[1-(2-Benzylamino-5-nitro-phenyl)-1-phenyl-meth-(Z)-ylidene]-amino}-acetic acid 
• 102725-58-6 N-benzylnitrazepam 

Relevant academic research and scientific papers

Exploring the influence of designer surfactant hydrophobicity in key C–C/C–N bond forming reactions

Designer micellar medium was explored for the transformation of diverse anilines to the corresponding densely substituted biologically relevant skatole derivatives in an aqueous medium via 5-exo-trig cyclization reaction. The scope of the reaction was extended to intermolecular Csp2-Csp2 and Csp2-N bond forming reactions in water. Systematic investigations revealed that altering hydrophobicity of surfactant influences the yield of both C–C and C–N bond forming reactions in water.

Micellar Catalysis of Organic Reactions. 18. Basic Hydrolysis of Diazepam and Some N-Alkyl Derivatives of Nitrazepam

Kinetic and mechanistic studies of the basic hydrolysis of several benzodiazepinone drugs have been carried out in the presence of micelles of cetyltrimethylammonium bromide (CTAB) and in aqueous solution.For diazepam, a change of mechanism from initial azomethine hydrolysis in water to initial amide hydrolysis in the presence of micelles of CTAB is indicated.For nimetazepam and N-benzylnitrazepam, initial amide hydrolysis was observed both in the presence of CTAB and in water.For the latter compounds, strong catalysis (50-100) of amide hydrolysis (phase 1) by micelles of CTAB was observed, while azomethine hydrolysis (phase 2) was only very weakly catalyzed (3-4-fold).For diazepam, the catalysis was smaller (9-18-fold), but this was accompanied by a mechanistic change so that here the actual catalysis of amide hydrolysis is masked.

2-Benzoyl-4-nitroanilides and their use as medicaments

New derivatives of 2-benzoyl-4-nitro anilides, their preparation and their use as medicaments. The new chemical derivatives of the invention have the general formula STR1 in which R represents a linear or branched alkyl group, an alkenyl group, a cycloalkyl group or a benzyl group, R1 represents a hydrogen atom, an alkyl group or a hydroxy alkyl group, R2 represents a hydroxy-alkyl, alkenyl or alkynyl group, possibly substituted one or more times by an alkyl radical, or a cycloalkyl group having three to six carbon atoms; R1 and R2 may furthermore form, with the nitrogen atom to which they are attached, a nitrogen heterocycle containing possibly a second heteroatom selected from among oxygen and nitrogen; under the condition, however, that when R2 represents a hydroxy-alkyl group R1 may not be a hydrogen atom. Use as hypnotic agents for the treatment of insomnia.