37556-05-1

Upstream product

• 23430-41-3 2-phenyl-1-propyl 4-methylbenzenesulfonate 
• 105-53-3 diethyl malonate 
• 75803-19-9 2-phenyl-1-propanol 
• 98-83-9 isopropenylbenzene 
• 685-87-0 Diethyl 2-bromomalonate 

Relevant academic research and scientific papers

Novel compounds

Compounds of formula I, or a salt thereof or a hydrate thereof, as follows: wherein X and Y are selected independently from hydrogen and aryl, which aryl is unsubstituted or substituted one or more times by hydroxy, hydroxyC1-6alkyl, C1-6alkoxyC1-6alkyl, aryl, heterocyclyl, amino, C1-6alkylamino, di(C1-6alkyl)amino, arylC1-6alkoxy, C1-6alkyl, C1-6alkoxy or halo, which alkyl or alkoxy groups are unsubstituted or substituted one or more times by halo; m and n are independently 0 to 3, provided that m and n are not both 0; A represents a single bond or is —(CRpa Rpb)p— wherein p is 1-3 and Rpa and Rpb are selected independently from hydrogen, C1-6alkyl, C1-6alkoxy and halo, which alkyl or alkoxy groups are independently substituted one or more times by halo; B represents a C4-8 saturated or unsaturated ring, which ring is unsubstituted or substituted one or more times by C1-6alkyl, C1-6alkoxy, aryl, aryloxy, hydroxy, oxo, halo, amino, C1-6alkylamino, di(C1-6 alkyl)amino, and C1-6alkylamido, which C1-6alkyl or C1-6alkoxy groups are unsubstituted or substituted one or more times by halo, which aryl group is unsubstituted or substituted one or more times by aryl, heterocyclyl, aryloxy, arylC1-6alkoxy, amino, C1-6alkylamino, di(C1-6alkyl)amino, arylC1-6alkyl, hydroxy, C1-6alkenoxy, C1-6alkoxy, halo, or C1-6alkyl, which C1-6alkyl may be substituted one or more times by halo, and which aryl group is linked to said ring by a single bond or is benzo-condensed therewith are ligands of the ORL-1 receptor.

Reaction with Umpolung of the Malonyl Radical

The malonyl radical 3 can be generated from chloro- or bromomalonate in a radical chain reaction.This radical reacts with enol ethers 6 to addition products 7 or substitution products 10.During the formation of 7 the adduct radicals 12 are trapped by tin

Charge Distribution Between Formally Identical Fragments: The McLafferty Rearrangement

The McLafferty rearrangement for 2,5-diphenyl-1-hexene and its deuterium labelled analogues has been investigated.The α-methylstyrene fragments originating from different parts of the molecular ion retain the charge with equal probability and afford identical metastable spectra.The geometry of the transition state is discussed.