37557-97-4

Upstream product

• 186581-53-3 diazomethane 
• 3592-44-7 bis(chloromethyl)sulfide 
• 7791-25-5 sulfuryl dichloride 

Downstream Products

• 103721-98-8 (4R,5R)-4-Chloro-5-(4-chloro-phenyl)-[1,3]oxathiolane 3,3-dioxide 
• 103721-97-7 (4R,5R)-4-Chloro-5-(4-methoxy-phenyl)-[1,3]oxathiolane 3,3-dioxide 
• 103722-02-7 (4R,5R)-4-Chloro-5-(3-chloro-phenyl)-[1,3]oxathiolane 3,3-dioxide 
• 103750-10-3 (4R,5R)-4-Chloro-5-((E)-styryl)-[1,3]oxathiolane 3,3-dioxide 
• 103722-01-6 (4R,5R)-4-Chloro-5-(3-methoxy-phenyl)-[1,3]oxathiolane 3,3-dioxide 
• 2765-42-6 2-(2-hydroxy-2-phenylethylsulfonyl)-1-phenyl-1-ethanol 
• 103722-08-3 2-Chloromethanesulfonyl-3-cyclohexyl-oxirane 
• 103722-00-5 (4R,5R)-4-Chloro-5-(2-methoxy-phenyl)-[1,3]oxathiolane 3,3-dioxide 
• 103721-96-6 4-chloro-5-phenyl-1,3-oxathiolane-3,3-dioxide 

Relevant academic research and scientific papers

CARBON-CARBON BOND FORMING REACTION OF BIS(CHLOROMETHYL)SULFONE WITH CARBONYL COMPOUNDS: GENERAL ROUTE TO AROMATIC 2-CHLOROVINYL COMPOUNDS AND α-HYDROXYALDEHYDES

Bis(chloromethyl)sulfone (1) has been proved to be a useful reagent for the synthesis of aromatic 2-chlorovinyl compounds (4) from aromatic aldehydes and of α-hydroxyaldehydes (5) from aliphatic carbonyl compounds with one carbon prolongation.The sec-butyllithium-aided reaction of 1 with aromatic aldehydes gives 1,3-oxathiolane-3,3-dioxides (2) which are converted to 4 in good yields by thermolysis.On the other hand, the sodium hydride-aided reaction of 1 with aliphatic carbonyl compounds is favorable to the formation of chloromethylsulfonyloxiranes (3).Titanium tetrachloride has been found to be an efficient reagent for hydrolysis of 3 to 5.