37579-77-4

Basic information

• Product Name: Glycine, N-[N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)-L-tyrosyl]-, phenylmethyl ester
• CAS NO: 37579-77-4
• Molecular Formula: C30H34N2O6
• Molecular Weight: 518.61
• Mol File: 37579-77-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Glycine, N-[N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)-L-tyrosyl]-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Glycine, N-[N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)-L-tyrosyl]-, phenylmethyl ester(37579-77-4)
• EPA Substance Registry System: Glycine, N-[N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)-L-tyrosyl]-, phenylmethyl ester(37579-77-4)

Safety Data

• Hazardous Substances Data: 37579-77-4(Hazardous Substances Data)

Upstream product

• 1738-76-7 glycine benzyl ester p-toluenesulfonic acid salt 
• 2130-96-3 O-benzyl-N-tert-butoxycarbonyl-L-tyrosine 
• 2462-31-9 benzyl 2-aminoacetate hydrochloride 

Downstream Products

• 41296-45-1 N-Boc-Tyr(Bn)-Gly-OH 
• 54905-47-4 pGlu-His-Trp-Ser-Tyr-Gly-Leu 
• 42497-28-9 p-Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg 

Relevant articles and documents

2,4-BIS(4-METHOXYPHENYL)-1,3,2,4-DITHIADIPHOSPHETANE 2,4-DISULFIDE, LR, AS A NEW ACTIVATION REAGENT IN PREPARATION OF PEPTIDES, AMIDES AND ESTERS

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An Approach to the Elucidation of Metabolic Breakdown Products of the Luteinizing Hormone-Releasing Hormone

Metabolic breakdown of the luteinizing hormone-releasing hormone (LH-RH) could lead to the following fragments containing pyroglutamic acid: pyroglutamic acid (1), pGlu-His (2), pGlu-His-Trp (3), pGlu-His-Trp-Ser (4), etc., and finally pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly (10).We have synthesized fragments 2-10 and successfully separated all ten metabolites and LH-RH by high-performance liquid chromatography (HPLC) with μBondapak C18 column.In a test of viability of the method, cochromatography of fragments 1-10 and LH-RH with the products of chymotryptic digestion of tritiated LH-RH showed radioactive peaks corresponding to the expected products, fragments 3 and 5.Analysis of the products of incubation of a rat kidney homogenate supernatant with LH-RH showed fragments 1-4 and LH-RH.The finding of breakdown at position 4 uncovers a new site of LH-RH breakdown and points the way to the design of potential LH-RH antagonists and agonists where the 4 position would be substituted with unnatural amino acids to prevent breakdown.