54905-47-4

Basic information

• Product Name: pGlu-His-Trp-Ser-Tyr-Gly-Leu
• CAS NO: 54905-47-4
• Molecular Weight: 872.935
• Mol File: 54905-47-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: pGlu-His-Trp-Ser-Tyr-Gly-Leu(CAS DataBase Reference)
• NIST Chemistry Reference: pGlu-His-Trp-Ser-Tyr-Gly-Leu(54905-47-4)
• EPA Substance Registry System: pGlu-His-Trp-Ser-Tyr-Gly-Leu(54905-47-4)

Safety Data

• Hazardous Substances Data: 54905-47-4(Hazardous Substances Data)

Upstream product

• 77112-05-1 Boc-Ser(Bzl)-Tyr(Bzl)-Gly-Leu-OBzl 
• 84636-30-6 Ser(Bzl)-Tyr(Bzl)-Gly-Leu-OBzl 
• 50715-56-5 Boc-Ser(Bzl)-Tyr(Bzl)-Gly-OEt 
• 100039-27-8 Tyr(Bzl)-Gly-OEt hydrochloride 
• 2130-96-3 O-benzyl-N-tert-butoxycarbonyl-L-tyrosine 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 23680-31-1 BOC-O-benzyl-L-serine 
• 13139-14-5 Boc-Trp-OH 
• 41296-45-1 N-Boc-Tyr(Bn)-Gly-OH 
• 84636-31-7 C₆₃H₇₀N₁₀O₁₁ 
• 40356-35-2 BOC-Tyr(OBzl)-Gly-OEt 
• 50715-57-6 Boc-Ser(Bzl)-Tyr(Bzl)-Glu-OH 
• 37579-77-4 Boc-Tyr(Bzl)-Gly-OBzl 

Relevant articles and documents

An Approach to the Elucidation of Metabolic Breakdown Products of the Luteinizing Hormone-Releasing Hormone

Metabolic breakdown of the luteinizing hormone-releasing hormone (LH-RH) could lead to the following fragments containing pyroglutamic acid: pyroglutamic acid (1), pGlu-His (2), pGlu-His-Trp (3), pGlu-His-Trp-Ser (4), etc., and finally pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly (10).We have synthesized fragments 2-10 and successfully separated all ten metabolites and LH-RH by high-performance liquid chromatography (HPLC) with μBondapak C18 column.In a test of viability of the method, cochromatography of fragments 1-10 and LH-RH with the products of chymotryptic digestion of tritiated LH-RH showed radioactive peaks corresponding to the expected products, fragments 3 and 5.Analysis of the products of incubation of a rat kidney homogenate supernatant with LH-RH showed fragments 1-4 and LH-RH.The finding of breakdown at position 4 uncovers a new site of LH-RH breakdown and points the way to the design of potential LH-RH antagonists and agonists where the 4 position would be substituted with unnatural amino acids to prevent breakdown.