375799-23-8Relevant academic research and scientific papers
Fluoresceinated FKBP12 ligands for a high-throughput fluorescence polarization assay
Dubowchik, Gene M.,Ditta, Jonathan L.,Herbst, John J.,Bollini, Sagarika,Vinitsky, Alexander
, p. 559 - 562 (2000)
Several fluoresceinated FKBP12 ligands have been prepared for a high-throughput fluorescence polarization assay. K(i)s for FKBP12 rotamase inhibition by these ligands range from 1.3 μM to 32 nM, and their design is based on X-ray crystal structures of FKBP12 complexed with known immunophilin ligands. (C) 2000 Elsevier Science Ltd. All rights reserved.
