375856-45-4

Upstream product

• 100-52-7 benzaldehyde 
• 314283-98-2 (2-Methyl-3-nitro-phenyl)-[1-phenyl-meth-(Z)-ylidene]-amine 

Downstream Products

• 709016-12-6 benzyl-(4-chloro-2-fluoro-benzyl)-(2-methyl-3-nitro-phenyl)-amine 
• 448956-69-2 N-[4-(allyloxy)benzyl]-N-benzyl-N-(2-methyl-3-nitrophenyl)amine 
• 448956-36-3 N,N-dibenzyl-N-(2-methyl-3-nitrophenyl)amine 
• 448952-94-1 N-{3-[benzyl(2-bromobenzyl)amino]-2-methylphenyl}methanesulfonamide 

Relevant academic research and scientific papers

Bile acid conjugates of a nonsteroidal glucocorticoid receptor modulator

Bile acid conjugates of a selective nonsteroidal glucocorticoid receptor modulator were prepared and evaluated. Potent GR binding conjugates that showed improved metabolic stability were discovered. However, cellular potency and pharmacokinetics were not substantially improved.

Discovery of novel nonsteroidal glucocorticoid receptor modulators

A new class of selective nonsteroidal glucocorticoid receptor modulators typified by N-{3-[benzyl-(4-chloro-2-fluoro-benzyl)-amino]-2-methyl-phenyl}- methanesulfonamide 19 has been discovered.