37592-62-4Relevant academic research and scientific papers
A mild catalytic synthesis of 2-oxazolines: Via oxetane ring-opening: Rapid access to a diverse family of natural products
Huang, Hai,Yang, Wen,Chen, Zuliang,Lai, Zengwei,Sun, Jianwei
, p. 9586 - 9590 (2019/11/05)
A new catalytic protocol for the expedient synthesis of oxazolines from oxetanes is disclosed. This mild process complements the conventional oxazoline synthesis based on non-catalytic cyclization of β-hydroxy or unsaturated amides. It is also a new addition to the reactivity profile of oxetanes leading to heterocycles. In the presence of In(OTf)3, various 3-amido oxetanes underwent smooth intramolecular cyclization to form the corresponding 2-oxazolines, including some valuable oxazoline-based bidentate ligands. This protocol also provides rapid access to various natural products and antibacterial molecules.
