37611-80-6

Basic information

• Product Name: 2-(O-AMINOPHENETHYL)-1-METHYLPIPERIDINE
• Synonyms: 2-(O-AMINOPHENETHYL)-1-METHYLPIPERIDINE
• CAS NO: 37611-80-6
• Molecular Formula: C₁₄H₂₂N₂
• Molecular Weight: 218.33788
• Mol File: 37611-80-6.mol

Chemical Properties

• Boiling Point: 342.6±15.0 °C(Predicted)
• Appearance: /
• Density: 1.001±0.06 g/cm3(Predicted)
• PKA: 9.95±0.10(Predicted)
• CAS DataBase Reference: 2-(O-AMINOPHENETHYL)-1-METHYLPIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(O-AMINOPHENETHYL)-1-METHYLPIPERIDINE(37611-80-6)
• EPA Substance Registry System: 2-(O-AMINOPHENETHYL)-1-METHYLPIPERIDINE(37611-80-6)

Safety Data

• Hazardous Substances Data: 37611-80-6(Hazardous Substances Data)

Usage

Chemical class

Piperidine compounds

Derived from

Combination of aminophenethyl and methylpiperidine groups

Usage

Building block for the synthesis of biologically active compounds

Potential applications

Development of new drugs for central nervous system disorders, cardiovascular diseases, and cancer

Additional applications

Versatile intermediate for the synthesis of diverse chemical compounds in organic chemistry

Upstream product

• 552-89-6 2-nitro-benzaldehyde 
• 2037-39-0 1,2-dimethylpyridinium methosulfate 

Downstream Products

• 951155-18-3 (+/-)-MPEC 
• 58754-06-6 4-bromo-2'-[2-(1-methyl-2-piperidyl)ethyl]benzanilide 
• 58754-48-6 encainide 
• 62414-73-7 (S)-2-[2-(1-methyl-2-piperidinyl)ethyl]benzenamine (1R,3S)-(+)-camphoric acid salt 
• 58754-11-3 4-dimethylamino-2'-[2-(1-methyl-2-piperidyl)ethyl]benzanilide 
• 37612-08-1 4-acetoxy-2'-[2-(1-methyl-2-piperidyl)ethyl]benzanilide 
• 58753-92-7 2'-[2-(1-methyl-2-piperidyl)ethyl]-p-toluanilide 
• 58753-93-8 2'-[2-(1-methyl-2-piperidyl)ethyl]picolinanilide 
• 37612-07-0 2'-[2-(1-methyl-2-piperidyl)ethyl]methanesulfonanilide 
• 66794-74-9 4-methoxy-2'-[2-(1-methyl-2-piperidyl)ethyl]benzanilide hydrochloride 

Relevant articles and documents

Process for the preparation of encainide

A new and novel process for the preparation of encainide (4-methoxy-2'-[2-(1-methyl-2-piperidyl)ethyl]-benzanilide) has been developed. The process utilizes α-picoline, O-nitrobenzaldehyde, and anisoyl chloride as starting materials.

Substituted piperidines

The compounds are of the heterocyclic class of 2-phenethylpiperidines having an amido substituent in the ortho position of the phenethyl moiety. Substituents in the ortho position include formamido, benzamido, cinnamamido, 2-thiophenecarboxamido, alkanesulfonamido and alkanoylamido. They are useful as antiarrhythmic and/or antiserotonin agents. The novel compounds are prepared by reaction of appropriately substituted o-aminophenethylpiperidines and the carbonyl or sulfonyl halides or anhydrides. Typical embodiments of this invention are 4-methoxy-2'-[2-(1-methyl-2-piperidyl)ethyl]benzanilide and 2'-[2-(1-methyl-2-piperidyl)ethyl]cinnamanilide.