37629-75-7Relevant academic research and scientific papers
Synthesis and biological evaluation of novel 4,5-disubstituted 2H-1,2,3-triazoles as cis-constrained analogues of combretastatin A-4
Madadi, Nikhil R.,Penthala, Narsimha R.,Howk, Kevin,Ketkar, Amit,Eoff, Robert L.,Borrelli, Michael J.,Crooks, Peter A.
, p. 123 - 132 (2015/09/15)
A series of combretastatin A-4 (CA-4) analogues have been prepared from (Z)-substituted diarylacrylonitriles (1a-1p) obtained in a two-step synthesis from appropriate arylaldehydes and acrylonitriles. The resulting 4,5-disubstituted 2H-1,2,3-triazoles wer
