37637-20-0

Usage

Uses

Used in Pharmaceutical Industry:
AZEPAN-2,5-DIONE is used as an intermediate in the production of pharmaceuticals for its ability to undergo various chemical reactions, contributing to the development of new medications.
Used in Agrochemical Industry:
AZEPAN-2,5-DIONE is utilized as an intermediate in the production of agrochemicals, playing a role in the synthesis of compounds that can enhance crop protection and yield.
Used in Organic Chemical Synthesis:
AZEPAN-2,5-DIONE is used as a building block for the synthesis of complex organic molecules, enabling the creation of a wide range of chemical products with diverse applications.
Used in Research and Development:
AZEPAN-2,5-DIONE is studied for its potential use in advancing organic chemical synthesis techniques, as its reactivity and structural properties allow for exploration and innovation in the development of new chemical processes and compounds.

Upstream product

• 2314-78-5 N-ethylsuccinimide 
• 82386-70-7 5-Benzoyloxy-2-azacycloheptanone 
• 637-88-7 1,4-Cyclohexanedione 

Downstream Products

• 19869-42-2 1-methyl-1,2,3,5,6,7-hexahydroazepin-4-one hydrochloride 
• 16803-07-9 1,4-dioxan-8-azaspiro[4.6]undecane 

Relevant academic research and scientific papers

Method for preparing N-methyl azepine-4-one hydrochloride

The invention discloses a method for preparing N-methyl azepine-4-one hydrochloride. According to the method, 4-oxime cyclohexanone is taken as a raw material, aza-cycloheptane-2,5-diketone is obtained under a Beckmann rearrangement condition, aza-cycloheptane-2,5-diketone and ethylene glycol are subjected to condensation to generate ketal, amide is reduced through red aluminum, methylation is performed, ethylene glycol is removed under a hydrochloric acid condition, and finally N-methyl azepine-4-one hydrochloride is obtained. The invention provides a safe, reliable and efficient synthetic route, the raw materials are low in price, the reaction conditions are mild, explosive diazomethane does not need to be used, methyl acrylate which is easy to polymerize and high in carcinogenesis is also not needed, and the method is more suitable for large-scale industrial production.

Azido-Schmidt reaction for the formation of amides, imides and lactams from ketones in the presence of FeCl3

Ketones undergo smooth rearrangement with TMSN3 in the presence of FeCl3 under extremely mild conditions to provide the corresponding amides, imides and lactams in good yields with high selectivity. This method is very useful for the preparation of a wide range of amides, imides and lactams from ketones. The use of FeCl3 makes this method simple, convenient and cost-effective.

SYNTHESIS AND ABSOLUTE CONFIGURATION OF 1,7-DIAZASPIRONONANE-2,6-DIONE

Synthesis and determination of absolute configuration of the title compound are described and its CD spectrum is presented.