37656-67-0

Usage

Uses

Used in Pharmaceutical Industry:
(4-CHLORO-PHENYL)-PIPERIDIN-4-YL-AMINE is used as a key intermediate in the synthesis of various medications, primarily for its role in creating antipsychotic and antihistamine drugs. Its unique structure allows for the development of compounds that can effectively target and modulate specific receptors in the body, contributing to the treatment of mental health disorders and allergic reactions.
Used in Agrochemical Industry:
In the agrochemical sector, (4-CHLORO-PHENYL)-PIPERIDIN-4-YL-AMINE serves as an intermediate in the production of pesticides and other crop protection agents. Its chemical properties enable the creation of compounds that can protect crops from pests and diseases, thereby ensuring food security and agricultural productivity.
Used in Research and Development:
(4-CHLORO-PHENYL)-PIPERIDIN-4-YL-AMINE is utilized as a building block in the research and development of new therapeutic agents. Its chemical structure provides a foundation for the design and synthesis of innovative compounds with potential applications in various medical fields, including the treatment of neurological disorders, cardiovascular diseases, and other health conditions.
Overall, (4-CHLORO-PHENYL)-PIPERIDIN-4-YL-AMINE is a versatile chemical compound with significant applications across different industries, particularly in the development and production of pharmaceuticals and agrochemicals, as well as in scientific research for the advancement of new therapeutic agents.

Upstream product

• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 56553-60-7 sodium tris(acetoxy)borohydride 
• 106-47-8 4-chloro-aniline 
• 76-05-1 trifluoroacetic acid 
• 401565-95-5 1-(tert-Butoxycarbonyl)-4-[(4-chlorophenyl)amino]piperidine 
• 37656-66-9 4-chloro-N-(1-ethoxycarbonyl-4-piperidinyl)aniline 
• 29976-53-2 N-ethoxycarbonyl-4-piperidone 

Downstream Products

• 63260-69-5 (1-allyl-piperidin-4-yl)-(4-chloro-phenyl)-amine 
• 1089209-42-6 1-[(2,3-dihydro-2,2-dimethyl-5-chloro-benzofuran-7-yl)-oxy]-3-[4-((4-chloro-phenyl)-amino)-piperidin-1-yl]-propane 
• 1089758-77-9 1-{[5-(N-methylsulfamoyl)-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl]-oxy}-3-[4-(4-chloro-phenyl-amino)-piperidin-1-yl]-propane 
• 1094173-08-6 C₃₁H₃₇ClN₄O 
• 1325211-08-2 (2R,3R)-3-(4-((4-chlorophenyl)amino)piperidin-1-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 

Relevant academic research and scientific papers

MULTIVALENT RAS BINDING COMPOUNDS

Described herein are compounds that modulate Ras signaling, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with altered Ras signaling. Further described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds and methods of using such compounds in the treatment of cell proliferative disorders, including cancer.

NOVEL ANTIFUNGAL TRIAZOLE DERIVATIVES

Disclosed are novel triazole derivatives. Exhibiting excellent antifungal activity and in vivo safety, they are useful for the treatment or prevention of fungal infections caused by a wide spectrum of fungi.

NOVEL ANTIFUNGAL TRIAZOLE DERIVATIVES

Disclosed are novel triazole derivatives. Exhibiting excellent antifungal activity and in vivo safety, they are useful for the treatment or prevention of fungal infections caused by a wide spectrum of fungi.

PIPERIDINE DERIVATIVES USEFUL AS HISTAMINE H3 ANTAGONISTS

Disclosed are novel compounds of the formula (I) or a pharmaceutically acceptable salt thereof, wherein: M1 and M3 are CH or N; M2 is CH, CF or N; Y is -C(=O)-, -C(=S)-, -(CH2)q-, -C(=NOR7)

COMPOUNDS USEFUL AS CHEMOKINE RECEPTOR ANTAGONISTS

The present invention relates to compounds useful as Chemokine Receptor antagonists. Compounds of general formula (I) are provided or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and compositions for the inhibition of Chemokine Receptors and also for the treatment of various diseases, conditions, or disorders, including acute or chronic inflammatory disease, cancer, and osteolytic bone disorders.

Novel compounds

The invention provides compounds of general formula (I) wherein Q, R, R2, R4, R5, R6, R7 and R8 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

New 4-arylaminopiperidines with antihypoxic and anticonvulsive activity

Several new bioanalogues of (±)-N-methyl-N-{1-[3-(4-fluorophenoxy)-2-hydroxy-propyl]piperidin-4- yl}benzothiazol-2-amine (1, sabeluzole, CAS 104383-17-7) were prepared by reacting 1,2-epoxy-3-aryloxypropanes with 4-arylaminopiperidines. Some of these derivatives showed enhanced activity in the potassium cyanide hypoxia test and in the pentetrazol convulsion test in mice compared to 1.

Aminohaloborane in Organic Synthesis. IX. Exclusive ortho Acylation Reaction of N-Monoaminoalkylanilines

The exclusive ortho acylation reaction of aniline derivatives using boron trichloride made possible the one-step synthesis of 2-acyl-N-monoaminoalkylanilines (1) and the corresponding imines (2) from N-monoaminoalkylanilines, even in the case of compounds with a bulky substituent at the nitrogen atom.Conventional methods only give 1 via elaborate procedures.Keywords: regioselective reaction; 2-acylaniline derivative; 2-acylaniline-imine derivative; boron trichloride