N-(4-chlorophenyl)piperidin-4-amine

Base Information

• Chemical Name: N-(4-chlorophenyl)piperidin-4-amine
• CAS No.: 37656-67-0
• Molecular Formula: C11H15ClN2
• Molecular Weight: 210.706
• European Community (EC) Number: 820-567-5
• Mol file: 37656-67-0.mol

Synonyms:N-(4-chlorophenyl)piperidin-4-amine;37656-67-0;(4-Chloro-phenyl)-piperidin-4-yl-amine;N-(4-chlorophenyl)-4-piperidinamine;SCHEMBL655632;4-(4-chlorophenylamino)piperidine;KCOHNRMFXQLTCW-UHFFFAOYSA-N;N-(4-chlorophenyl)4-piperidinamine;AKOS004120340;N-(4-chlorophenyl)piperidine-4-amine;(4-Chloro-phenyl)-piperidin-4yl-amine;FS-1991;CS-0236240;FT-0741564;EN300-1698815;(4-chloro-phenyl)-piperidin-4-yl-amine, AldrichCPR;Z728910424

Chemical Property of N-(4-chlorophenyl)piperidin-4-amine

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 210.0923762
• Heavy Atom Count: 14
• Complexity: 161

Purity/Quality:

99% ^*data from raw suppliers

AS025095:(4-Chloro-phenyl)-piperidin-4-yl-amine 97 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CNCCC1NC2=CC=C(C=C2)Cl

Technology Process of N-(4-chlorophenyl)piperidin-4-amine

There total 11 articles about N-(4-chlorophenyl)piperidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-chloro-N-(1-ethoxycarbonyl-4-piperidinyl)aniline (37656-66-9) → N-(4-chlorophenyl)-4-piperidinamine (37656-67-0)

Guidance literature:

With hydrogenchloride; In water; for 16h; Heating;

Reference yield: 91.0%

1-(tert-Butoxycarbonyl)-4-[(4-chlorophenyl)amino]piperidine (401565-95-5) → N-(4-chlorophenyl)-4-piperidinamine (37656-67-0)

Guidance literature:

1-(tert-Butoxycarbonyl)-4-[(4-chlorophenyl)amino]piperidine; With hydrogenchloride; In ethyl acetate; at 0 - 20 ℃; for 2h; Inert atmosphere;

With potassium carbonate; In methanol; at 20 ℃; for 0.5h;

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) + sodium tris(acetoxy)borohydride (56553-60-7) + 4-chloro-aniline (106-47-8) + trifluoroacetic acid (76-05-1) → N-(4-chlorophenyl)-4-piperidinamine (37656-67-0)

Guidance literature:

With acetic acid; In dichloromethane;

upstream raw materials:

4-chloro-N-(1-ethoxycarbonyl-4-piperidinyl)aniline

4-chloro-aniline

N-ethoxycarbonyl-4-piperidone

N-tert-butyloxycarbonylpiperidin-4-one

Downstream raw materials:

(1-allyl-piperidin-4-yl)-(4-chloro-phenyl)-amine

C₃₁H₃₇ClN₄O

(2R,3R)-3-(4-((4-chlorophenyl)amino)piperidin-1-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

1-{[5-(N-methylsulfamoyl)-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl]-oxy}-3-[4-(4-chloro-phenyl-amino)-piperidin-1-yl]-propane

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