376582-47-7

Basic information

• Product Name: 4-bromo-3-(3,4-difluoro-phenyl)-2-(4-fluoro-phenyl)-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-butyramide
• CAS NO: 376582-47-7
• Molecular Weight: 620.469
• Mol File: 376582-47-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-bromo-3-(3,4-difluoro-phenyl)-2-(4-fluoro-phenyl)-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-butyramide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-3-(3,4-difluoro-phenyl)-2-(4-fluoro-phenyl)-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-butyramide(376582-47-7)
• EPA Substance Registry System: 4-bromo-3-(3,4-difluoro-phenyl)-2-(4-fluoro-phenyl)-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-butyramide(376582-47-7)

Safety Data

• Hazardous Substances Data: 376582-47-7(Hazardous Substances Data)

Upstream product

• 103343-66-4 (S)-3-amino-1-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one 
• 376584-21-3 3-(3,4-difluoro-phenyl)-2-(4-fluoro-phenyl)-pent-4-enoic acid (1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-amide 
• 564462-34-6 3-(3,4-difluoro-phenyl)-2-(4-fluoro-phenyl)-4-hydroxy-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-butyramide 
• 376584-20-2 (2S,3R)-3-(3,4-Difluoro-phenyl)-2-(4-fluoro-phenyl)-pent-4-enoic acid 

Relevant articles and documents

Design and synthesis of highly potent benzodiazepine γ-secretase inhibitors: Preparation of (2S,3R)-3-(3,4- difluorophenyl)-2-(4-fluorophenyl)-4-hydroxy-N-((3S)-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1H-benzo[e][1,4]-diazepin-3-yl)butyramide by use of an as

Novel benzodiazepine-containing γ-secretase inhibitors for potential use in Alzheimer's disease have been designed that incorporate a substituted hydrocinnamide C-3 side chain. A syn combination of α-alkyl or aryl and β-hydroxy or hydroxymethyl substituen