376591-94-5

Usage

Uses

Used in Pharmaceutical Industry:
2'-Methoxy-3'-nitro-biphenyl-3-carboxylic acid is used as a reagent for the preparation of pyrazolone derivatives, which are important in the treatment of thrombocytopenia. Thrombocytopenia is a medical condition characterized by a low blood platelet count, leading to an increased risk of bleeding. Pyrazolone derivatives, synthesized using 2'-Methoxy-3'-nitro-biphenyl-3-carboxylic acid, have been found to be effective in managing this condition by promoting platelet production and improving platelet function.

Upstream product

• 25487-66-5 3-Carboxyphenylboronic acid 
• 98775-19-0 2-bromo-6-nitrophenyl methyl ether 
• 13073-25-1 2-bromo-6-nitro-phenol 
• 95-56-7 2-hydroxybromobenzene 

Downstream Products

• 1257792-64-5 3'-amino-2'-hydroxy-biphenyl-3-carboxylic acid hydrobromide 
• 376592-93-7 3′-amino-2′-hydroxy biphenyl-3-carboxylic acid 
• 376591-95-6 2'-hydroxy-3'-nitro-biphenyl-3-carboxylic acid 
• 1176777-42-6 (Z)-2'-hydroxy-3'-[N'-(1-indan-5-yl-3-methyl-5-oxo-1,5-dihydropyrazol-4-ylidene)hydrazino]biphenyl-3-carboxylic acid 

Relevant academic research and scientific papers

BICYCLO-SUBSTITUTED PYRAZOLON AZO DERIVATIVES PHARMACEUTCIAL SALTS, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF

The present invention relates to bicyclo-substituted pyrazolon azo derivatives pharmaceutical acceptable salts of formula (I), methods for their preparation, pharmaceutical compositions containing the same and their use as a therapeutic agent, especially as thrombopoietin (TPO) mimetics and their use as agonists of thrombopoietin receptor. The definition of substituents in formula (I) are the same as the description.

SALTS OF BICYCLO-SUBSTITUTED PYRAZOLON AZO DERIVATIVES, PREPARATION METHOD AND USE THEREOF

The present invention relates to pharmaceutically acceptable salts of bicycle-substituted pyrazolon azo derivatives represented by general formula (I), methods for their preparation, pharmaceutical compositions comprising the same and their use as a therapeutic agent, especially as thrombopoietin (TPO) mimetics, and their use as agonists of thrombopoietin receptor. The definitions of substituents in general formula (I) are the same as the description.

BICYCLO-SUBSTITUTED PYRAZOLON AZO DERIVATIVES, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF

The bicyclo-substituted pyrazolon-azo derivatives of formula (I) or pharmaceutical acceptable salts, hydrates or solvates thereof, methods for their preparation, pharmaceutical compositions containing the same and their use as a therapeutic agent, especially as thrombopoietin (TPO) mimetics and their use as agonists of thrombopoietin receptor are disclosed. The definition of substituents in formula (I) are the same as defined in the description.

Thrombopoietin mimetics

Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.

Regulated activation of cell-membrane receptors by metal-chelating agonists

Invented is a regulated activation of cell-membrane receptors by small molecule agents. Also invented is a method to render a cell-membrane receptor responsive to the activation by small molecule compounds by specific single point mutations in the transmembrane region.