98775-19-0

Usage

Chemical Properties

White to off-white powder

InChI:InChI=1/C7H6BrNO3/c1-12-7-5(8)3-2-4-6(7)9(10)11/h2-4H,1H3

Upstream product

• 578-57-4 2-bromoanisole 
• 3970-37-4 1-bromo-2-chloro-3-nitrobenzene 
• 124-41-4 sodium methylate 
• 95-56-7 2-hydroxybromobenzene 
• 13073-25-1 2-bromo-6-nitro-phenol 
• 74-88-4 methyl iodide 
• 27684-84-0 5-bromo-2-nitrophenol 

Downstream Products

• 13073-25-1 2-bromo-6-nitro-phenol 
• 1257792-64-5 3'-amino-2'-hydroxy-biphenyl-3-carboxylic acid hydrobromide 
• 1257792-68-9 5-(2-methoxy-3-nitrophenyl)furan-2-carboxylic acid 
• 1257792-69-0 5-(3-amino-2-methoxyphenyl)furan-2-carboxylic acid 
• 1257792-70-3 5-(3-amino-2-hydroxy-phenyl)-furan-2-carboxylic acid hydrobromide 
• 1257792-74-7 4-(3-nitro-2-methoxyphenyl)furan-2-carboxylic acid 
• 1257792-75-8 4-(3-amino-2-methoxyphenyl)furan-2-carboxylic acid 
• 1257792-76-9 4-(3-amino-2-hydroxyphenyl)furan-2-carboxylic acid hydrobromide 
• 1609393-90-9 2-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline 
• 1253380-75-4 4-[2-(methyloxy)-3-nitrophenyl]morpholine 
• 376591-94-5 2'-methoxy-3'-nitrobiphenyl-3-carboxylic acid 
• 1257792-67-8 2-(2-methoxy-3-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 860584-68-5 2-bromo-6-iodoanisole 
• 98775-22-5 (2-Bromo-6-nitro-phenyl)-cyclohexyl-amine 

Relevant academic research and scientific papers

AMIDE-SUBSTITUTED HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF CONDITIONS RELATED TO THE MODULATION OF IL-12, IL-23 AND/OR IFN-ALPHA

Compounds having the following formula I: or a stereoisomer or pharmaceutically-acceptable salt thereof, where R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-2

Heterocyclic compounds as TYK2 inhibitors and methods of synthesis and use

The invention provides a heterocyclic compound serving as a TYK2 inhibitor and a synthesis and use method, and particularly provides a compound shown as a formula (I), a preparation method of the compound and application of the compound serving as the TYK2 inhibitor. The compounds of the present invention exhibit excellent inhibitory activity against TYK2.

ALKYL-AMIDE-SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFNα RESPONSES

Compounds having the following formula I: or a stereoisomer or a pharmaceutically-acceptable salt thereof, wherein R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNα by acting on Tyk-2 to cause signal transduction inhibition.

BICYCLO-SUBSTITUTED PYRAZOLON AZO DERIVATIVES PHARMACEUTCIAL SALTS, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF

The present invention relates to bicyclo-substituted pyrazolon azo derivatives pharmaceutical acceptable salts of formula (I), methods for their preparation, pharmaceutical compositions containing the same and their use as a therapeutic agent, especially as thrombopoietin (TPO) mimetics and their use as agonists of thrombopoietin receptor. The definition of substituents in formula (I) are the same as the description.

NOVEL COMPOUND WITH ANTIBACTERIAL ACTIVITY

A compound represented by the general formula (I) or a salt thereof having a potent antibacterial activity against bacteria that have acquired resistance to quinolones, and a medicament for prophylactic and/or therapeutic treatment of an infectious disease containing the compound or a salt thereof as an active ingredient, as well as a medicament for prophylactic and/or therapeutic treatment of an infectious disease containing a combination of the compound or a salt thereof, and a quinolone.

ALKYL-AMIDE-SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFNALPHA RESPONSES

Compounds having the following formula (I): or a stereoisomer or a pharmaceutically-acceptable salt thereof, wherein R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNα by acting on Tyk-2 to cause signal transduction inhibition.

AMIDE-SUBSTITUTED HETEROCYCLIC COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHα RESPONSES

Compounds having the following formula I: or a stereoisomer or pharmaceutically-acceptable salt thereof, where R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNa, by acting on Tyk-2 to cause signal transduction inhibition.

INDOLINONE ANALOGUES

The present invention encompasses compounds of general formula (I) wherein the groups R1 to R4, A1 and A2 have the meanings given in the claims and in the specification. The compounds of the invention are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation pharmaceutical preparations containing such compounds and their uses as a medicament.

INDOLINONE ANALOGUES AS BRD4 INHIBITORS

The present invention encompasses compounds of general formula (I) wherein the groups R1 to R4, A1 and A2 have the meanings given in the claims and in the specification. The compounds of the invention are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation pharmaceutical preparations containing such compounds and their uses as a medicament.

PYRIMIDINE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE 1 (S1P1) RECEPTOR AGONISTS

Disclosed are pyrimidine derivatives for use as a sphingosine 1-phosphate 1 (S1P1) receptor agonists, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of conditions or diseases mediated by S1P1 receptors, particularly multiple sclerosis.