37663-46-0

Usage

Uses

Used in Pharmaceutical Industry:
Spiro[isobenzofuran-1(3H),4'-piperidin]-3-one is used as a key intermediate in the synthesis of cyclin-dependent kinase (CDK) inhibitors. These inhibitors are important for the development of drugs targeting various diseases, including cancer, by disrupting the cell cycle and preventing uncontrolled cell proliferation.
Used in Research and Development:
In the field of medicinal chemistry, Spiro[isobenzofuran-1(3H),4'-piperidin]-3-one serves as a valuable building block for the design and synthesis of novel compounds with potential therapeutic applications. Its unique structure allows researchers to explore new avenues in drug discovery and development.
Used in Chemical Synthesis:
Spiro[isobenzofuran-1(3H),4'-piperidin]-3-one can be utilized in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals. Its versatile structure makes it a useful component in the creation of new molecules with desired properties and functions.

Upstream product

• 32664-13-4 2-(2-bromo-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole 
• 54595-99-2 1-benzyl-4-[2-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-phenyl]-piperidin-4-ol 
• 93-98-1 N-phenyl benzoyl amide 
• 37663-42-6 1'-benzylspiro[isobenzofuran-1(3H),4'-piperidine]-3-one 
• 54596-21-3 2-bromo-N-(2-hydroxy-1,1-dimethylethyl)benzamide 
• 3612-20-2 1-phenylmethyl-4-piperidone 

Downstream Products

• 438190-93-3 1'-(trans-4-Ethoxycarbonyl-cyclohexylmethyl)carbamoyl-spiro [isobenzofuran-1,4'piperidin]3-one 
• 438190-64-8 (5-(3-methoxyphenyl)-1H-benzimidazol-2-yl)-spiro[isobenzofuran-1,4'-piperidin]-3-one 
• 438190-65-9 1'-(5-phenyl-1H-imidazo[4,5-b]pyrazin-2-yl)-spiro[isobenzofuran-1,4'-piperidin]-3-one 
• 915104-45-9 N-(4-Chlorophenyl)-3-oxo-1'H,3H-spiro[2-benzofuran-1,4'-piperidine]-1'-carbothioamide 
• 328232-23-1 C₂₂H₂₀N₄O₃ 
• 1175705-86-8 C₂₂H₁₉N₃O₃S 
• 1175705-81-3 C₂₂H₂₀N₄O₃ 
• 1175705-74-4 C₂₃H₂₀N₄O₃ 
• 1101026-34-9 C₂₃H₂₀N₄O₃ 
• 1175705-88-0 C₂₁H₁₈N₄O₃S 
• 1175706-03-2 C₂₃H₁₉ClN₄O₃ 
• 1175706-05-4 C₂₃H₁₉ClN₄O₃ 
• 1175706-07-6 C₂₄H₂₂N₄O₄ 
• 1175706-10-1 C₂₄H₂₂N₄O₄ 

Relevant academic research and scientific papers

INDOL-3-YL-CARBONYL-SPIRO-PIPERIDINE DERIVATIVES AS V1A RECEPTOR ANTAGONISTS

The invention relates to indol-3-yl-carbonyl-spiro-piperidine derivatives which act as V1a receptor antagonists and which are represented by Formula I: wherein the spiro-piperidine head group A and the residues R1, R2 and R3 are as defined herein. The invention further relates to pharmaceutical compositions containing such compounds, methods for preparing the compounds and pharmaceutical compositions, and their use in the treatment of dysmenorrhea, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, obsessive compulsive disorder, anxious and depressive disorders.

Aryl substituted heterocycles

The present invention concerns the novel use of aryl substituted heterocycles of formula I, set out below, which antagonize the pharmacological actions of one of ent endogenous neuropeptide tachykinins an the neurokinin 2 (NK2) receptor making them useful whenever such antagonism is desired, such as in the treatment of asthma and related conditions. The invention also provides pharmaceutical compositions containing the aryl substituted heterocycles for use in such treatment. Certain novel aryl substituted heterocycles of formula I and novel intermediates for their manufacture are also provided. STR1