376646-71-8

Basic information

• Product Name: 1-Piperazineethanol, 4-(4-aminophenyl)-a-(2,4-difluorophenyl)-a-(1H-1,2,4-triazol-1-ylmethyl) -
• CAS NO: 376646-71-8
• Molecular Formula: C21H24F2N6O
• Molecular Weight: 414.458
• Mol File: 376646-71-8.mol

Chemical Properties

• CAS DataBase Reference: 1-Piperazineethanol, 4-(4-aminophenyl)-a-(2,4-difluorophenyl)-a-(1H-1,2,4-triazol-1-ylmethyl) -(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperazineethanol, 4-(4-aminophenyl)-a-(2,4-difluorophenyl)-a-(1H-1,2,4-triazol-1-ylmethyl) -(376646-71-8)
• EPA Substance Registry System: 1-Piperazineethanol, 4-(4-aminophenyl)-a-(2,4-difluorophenyl)-a-(1H-1,2,4-triazol-1-ylmethyl) -(376646-71-8)

Safety Data

• Hazardous Substances Data: 376646-71-8(Hazardous Substances Data)

Upstream product

• 86386-77-8 1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole methanesulfonate 
• 6269-89-2 1-(4-Nitrophenyl)piperazine 

Downstream Products

• 1312759-95-7 N-(4-(4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]piperazin-1-yl)phenyl)dodecanamide 
• 1312759-92-4 N-(4-(4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]piperazin-1-yl)phenyl)heptanamide 
• 1312759-93-5 N-(4-(4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]piperazin-1-yl)phenyl)octanamide 
• 1312759-94-6 N-(4-(4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]piperazin-1-yl)phenyl)decanamide 
• 877611-93-3 N-(4-(4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]piperazin-1-yl)phenyl)propionamide 
• 1312759-85-5 2-chloro-N-(4-(4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]piperazin-1-yl)phenyl)acetamide 
• 1312759-96-8 N-(4-(4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]piperazin-1-yl)phenyl)palmitamide 
• 1312759-88-8 N-(4-(4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]piperazin-1-yl)phenyl)isobutanamide 
• 1312759-87-7 N-(4-(4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]piperazin-1-yl)phenyl)-2,2,2-trifluoroacetamide 
• 1312759-90-2 N-(4-(4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]piperazin-1-yl)phenyl)hexanamide 
• 877611-94-4 N-(4-(4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]piperazin-1-yl)phenyl)butanamide 

Relevant articles and documents

Design, synthesis and antifungal activities of novel 1,2,4-triazole derivatives

A series of novel 1,2,4-triazole derivatives with a 4-(4-substitutedphenyl) piperazine side chain were designed and synthesized based on the structure of lanosterol 14α-demethylase (CYP51). Their antifungal activities against eight human pathogenic fungi

Synthesis and evaluation of novel 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-[(4-substitutedphenyl)-piperazin-1-yl]-propan-2-ols as antifungal agents

A series of 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-[(4-substitutedphenyl)-piperazin-1-yl]-propan-2-ols have been designed and synthesized on the basis of the structure-activity relationships and antimycotic mechanism of azole antifungal agents

New azoles with antifungal activity: Design, synthesis, and molecular docking

In order to search for many target compounds with excellent activities, a series of 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluoro-phenyl)-3-[(4-substituted phenyl)-piperazin-1-yl]-propan-2-ols were designed, synthesized, and evaluated as antifungal agents. Re