37669-01-5

Usage

InChI:InChI=1/C7H12O4/c1-7(2)10-5(3-8)6(4-9)11-7/h3,5-6,9H,4H2,1-2H3/t5-,6+/m1/s1

Upstream product

• 58645-35-5 3,4-O-isopropylidine L-arabinopyranose 
• 127743-12-8 [(4S,5R)-2,2-Dimethyl-5-((E)-styryl)-[1,3]dioxolan-4-yl]-methanol 

Downstream Products

• 114817-96-8 (4S,5R)-2,2-dimethyl-4-hydroxymethyl-5-vinyl-1,3-dioxolane 
• 120142-89-4 2,3-O-isopropylidene-β-L-erythrofuranosyl 2,3-O-isopropylidene-β-L-erythrofuranoside 

Relevant academic research and scientific papers

Chiron Approaches to the Antitumor Natural Product Fuzanin D

Fuzanin D, a pyridine-containing natural product, which exhibits cytotoxic activity against DLD-1 cells, is synthesized in a concise manner using l-arabinose or ethyl l-lactate as chiral pool substrates in nine steps (14.4% overall yield) and six steps (30.8% overall yield), respectively. The key steps involve Wittig olefination and olefin cross--metathesis.

L-erythrosyl nucleosides

This invention relates to α and β-L-erythrosyl nucleosides of the formula (I), wherein the nucleoside substitution on the erythrosyl carbohydrate molecule comprises a substituted or unsubstituted purine (adenine or guanine) or pyrimidine (cytosine, uracil, thymine and hypoxanthine) base. Also provided are methods to make the α and β-L-erythrosyl nucleosides and methods of using such to treat cancer in a mammal.