37673-23-7

Basic information

• Product Name: decyl 5-oxo-L-prolinate
• Synonyms: decyl 5-oxo-L-prolinate;(S)-5-Oxopyrrolidine-2-carboxylic acid decyl ester;Pyroglutamic acid decyl ester
• CAS NO: 37673-23-7
• Molecular Formula: C₁₅H₂₇NO₃
• Molecular Weight: 269.37978
• EINECS: 253-591-4
• Mol File: 37673-23-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 412°Cat760mmHg
• Flash Point: 203°C
• Appearance: /
• Density: 1.007g/cm³
• Vapor Pressure: 5.35E-07mmHg at 25°C
• Refractive Index: 1.469
• PKA: 14?+-.0.40(Predicted)
• CAS DataBase Reference: decyl 5-oxo-L-prolinate(CAS DataBase Reference)
• NIST Chemistry Reference: decyl 5-oxo-L-prolinate(37673-23-7)
• EPA Substance Registry System: decyl 5-oxo-L-prolinate(37673-23-7)

Safety Data

• Hazardous Substances Data: 37673-23-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H27NO3/c1-2-3-4-5-6-7-8-9-12-19-15(18)13-10-11-14(17)16-13/h13H,2-12H2,1H3,(H,16,17)/t13-/m0/s1

Upstream product

• 112-30-1 1-Decanol 
• 98-79-3 L-Pyroglutamic acid 

Relevant articles and documents

Flow processing of microwave-assisted (heterogeneous) organic reactions

A commercially available continuous-flow reactor was adapted to run three organic reactions, e.g. two heterogeneous and one homogeneous mixture under microwave heating. The setup was operated either as a batch-loop reactor for running a biocatalyzed esterification of (R,S)-1-phenylethanol with vinyl acetate and the esterification of (S)-pyroglutamic acid with n-decanol (i.e., Laurydone process) or in a single pass for the aspirin synthesis as a homogeneous mixture. The tubular reactor has been characterized to perform a series of three equally sized, continuously operated stirred tank reactors on average. Although the (operational) costs of the microwave-heated tubular reactor are higher than conventionally heated processes in fine chemical operations, it was demonstrated that the experimental data can be used for process design. Plugging remains an important obstacle to be dealt with. However, benefits with respect to safety and scalability are expected to enable a fair compensation for the costs when implementing this novel technique.

Cosmetic composition containing DOPA derivatives

A composition for topical application to human hair or skin contains a chemical analogue of dihydroxyphenyl alanine (DOPA). This chemical analogue can be absorbed by skin or by a hair follicle and metabolised in-vivo, thus leading to the formation of melanin in skin or to the growth of melanin-pigmented hair. Consequently the composition can give controlled skin darkening to mimic sun-induced tanning or can bring about the growth of dar hair in place of the grey or white hair.

Cosmetic composition

A composition suitable for topical application to mammalian skin or hair for inducing, maintaining or increasing hair growth comprises: (i) a first chemical inhibitor chosen from proteoglycanase inhibitors, glycosaminoglycanase inhibitors, glycosaminoglycan chain cellular uptake inhibitors or mixtures thereof; and (ii) a cosmetically acceptable vehicle for the chemical inhibitor; provided that when the first chemical inhibitor is a weak inhibitor, such that a 1 mM aqueous solution of the inhibitor reduces proteoglycanase activity, glycosaminoglycanase activity or cellular uptake of glycosaminoglycan chains, by from 5 to 50%, in accordance with at least one of the assay tests as herein described, then there is also present in the composition a second chemical inhibitor and/or an activity enhancer. When minoxidil is the sole chemical inhibitor, then the activity enhancer is a penetration enhancer chosen from a limited number of materials, including certain esters and cationic polymers. The total amount of chemical inhibitor present in the composition is sufficient to increase hair growth in the rat, when said composition is applied topically thereto, by at least 10% more than that obtainable using a control composition from which the said inhibitors have been omitted.