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Z-PRO-GLY-GLY-OH is a peptide compound consisting of four amino acid residues: Z-protected proline (Z-PRO), glycine (GLY), and two additional glycine residues (GLY-GLY), with a hydroxyl group (OH) at the end. The Z-protection group is a chemical modification that temporarily blocks the side chain of proline, preventing unwanted side reactions during peptide synthesis. This specific sequence is of interest in the field of peptide chemistry and may have potential applications in drug development, as it can be used to create stable and functional peptide structures. The presence of glycine, the smallest amino acid, contributes to the flexibility and solubility of the peptide, while the hydroxyl group at the C-terminus allows for further chemical modifications or interactions.

37700-65-5

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37700-65-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 37700-65-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,7,7,0 and 0 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 37700-65:
(7*3)+(6*7)+(5*7)+(4*0)+(3*0)+(2*6)+(1*5)=115
115 % 10 = 5
So 37700-65-5 is a valid CAS Registry Number.

37700-65-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-[(Benzyloxy)carbonyl]-L-prolylglycylglycine

1.2 Other means of identification

Product number -
Other names N-[N-[(benzoyloxy)carbonyl]-L-phenylalanyl]-L-valine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:37700-65-5 SDS

37700-65-5Relevant academic research and scientific papers

Organocatalyzed Asymmetric Aldol Reaction of α-Keto Amides with A Tripeptide Catalyst

Kon, Kazumasa,Takai, Hiromu,Kobayashi, Takumu,Kohari, Yoshihito,Murata, Miki

supporting information, p. 829 - 832 (2021/02/26)

An organocatalyzed asymmetric aldol reaction of α-keto amides was developed. An N-terminal 4- trans -siloxyproline-based tripeptide with an l - tert -leucine unit adjacent to the 4- trans -siloxyproline residue was used to catalyze the reaction between various α-keto amides and acetone, to produce the corresponding aldol adducts with up to 99% yield and 91% ee.

Unnatural tripeptide as highly enantioselective organocatalyst for asymmetric aldol reaction of isatins

Kon, Kazumasa,Kohari, Yoshihito,Murata, Miki

supporting information, p. 415 - 418 (2019/01/05)

The development of unnatural tripeptides as highly enantioselective organocatalysts for the asymmetric aldol reaction of isatins was achieved. H-Pro-Gly-D-Ala-OH with the D-alanine residue as the C-terminal amino acid residue expressed the best enantioselectivity. The H-Pro-Gly-D-Ala-OH-catalyzed reaction of isatins gave various aldol adducts with up to 93% yield and up to 97% ee. Investigation of the transition state via DFT calculation revealed that high optical purity was realized by the D-alanine controlled steric environment.

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