37705-82-1

Usage

Uses

Used in Pharmaceutical Industry:
5-Amino-2-fluorobenzonitrile is used as a synthetic intermediate for the production of pharmaceuticals. It plays a crucial role in the development of new drugs and the modification of existing ones, contributing to advancements in medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 5-Amino-2-fluorobenzonitrile is employed as a precursor in the synthesis of agrochemicals. It aids in the creation of compounds that can be used in pest control, crop protection, and other agricultural applications, enhancing crop yields and ensuring food security.
Safety Precautions:
It is important to handle 5-amino-2-fluorobenzonitrile with care, as it can be harmful if ingested, inhaled, or comes into contact with skin and eyes. To ensure safety, appropriate protective measures should be taken when working with 5-AMINO-2-FLUOROBENZONITRILE. It should be stored in a cool, well-ventilated area and kept away from incompatible substances to prevent any potential hazards.

InChI:InChI=1/C3H5BrFNO/c1-6-3(7)2(4)5/h2H,1H3,(H,6,7)

Upstream product

• 4110-33-2 2,4-dinitrobenzonitrile 
• 98-10-2 benzenesulfonamide 
• 610-30-0 2,4-dinitrobenzoic acid 
• 87376-25-8 2-amino-4-nitro-benzonitrile 
• 5131-60-2 4-chloro-1,3-phenylenediamine 
• 57-13-6 urea 

Downstream Products

• 67451-20-1 N-[2-Cyano-5-(ethoxyoxalyl-amino)-phenyl]-oxalamic acid ethyl ester 
• 53325-60-3 dimethyl N,N'-(4-cyano-m-phenylene)dioxamate 
• 67451-33-6 N,N'-(4-cyano-m-phenylene)-dioxamic acid 
• 125103-72-2 N-[2-Cyano-5-(2,4-dioxo-4-p-tolyl-butyrylamino)-phenyl]-2,4-dioxo-4-p-tolyl-butyramide 
• 125103-71-1 N-[2-Cyano-5-(2,4-dioxo-4-phenyl-butyrylamino)-phenyl]-2,4-dioxo-4-phenyl-butyramide 
• 125103-74-4 4-(4-Chloro-phenyl)-N-{5-[4-(4-chloro-phenyl)-2,4-dioxo-butyrylamino]-2-cyano-phenyl}-2,4-dioxo-butyramide 

Relevant academic research and scientific papers

UiO-66/btb/Pd as a stable catalyst reduction of 4-nitrophenol into 4-aminophenol

In order to synthesize highly sparse nanoparticles, UiO-66-NH2 can be utilized as an appropriate support. It has great surface area, which is functionalized by 1,3-bis(dimethylthiocarbamoyloxy)benzene compounds that can act as the powerful performers, hence, the Pd (II) is a complex without aggregate over the UiO-66-NH2 microspheres structures (UiO-66/btb/Pd). Nitro-aromatic pollution in industrial waste streams threat wellbeing of water resources. The produced UiO-66/btb/Pd nanocatalyst showed appropriate catalytic activity for reduce nitro-aromatic compounds in aqueous solution. XRD, EDS, SEM, FT-IR, and TEM were utilized for characterizing the nanostructures UiO-66/btb/Pd.

DFNS/PEI/Cu Nanocatalyst for Reduction of Nitro-aromatic Compounds

Abstract: Nitro-aromatic pollution in industrial waste streams threat wellbeing of water resources. This study investigates the performance of a copper-based nano catalyst to reduce nitro-aromatic compounds in aqueous solution. Anchoring Cu NPs within the nano spaces of a fibrous silicate with high surface area, and simple accessibility of active sites were successfully established by a facile approach to produce a novel nanocatalyst (DFNS/PEI/Cu). DFNS displayed different properties such as dandelion-like shape, high surface area, and simple availability of active sites. Immobilization of the Cu NPs on DFNS nanospheres not only prevented their aggregation, but also considerably improved the availability of the catalytic active sites. The DFNS/PEI/Cu nanocatalyst demonstrated great catalytic activities for the reduction of nitro compounds under green conditions. Our findings show fibrous DFNS and Cu NPs as a helpful platform for the fabrication of noble metal-based affordable nanocatalyst for many catalytic applications. Graphic Abstract: DFNS/PEI/Cu nanocatalyst as a new adsorbents for the reduction of nitro compounds[Figure not available: see fulltext.]

Half-Sandwich Ruthenium Complexes of Amide-Phosphine Based Ligands: H-Bonding Cavity Assisted Binding and Reduction of Nitro-substrates

We present synthesis and characterization of two half-sandwich Ru(II) complexes supported with amide-phosphine based ligands. These complexes presented a pyridine-2,6-dicarboxamide based pincer cavity, decorated with hydrogen bonds, that participated in the binding of nitro-substrates closer to the Ru(II) centers, which is further supported with binding and docking studies. These ruthenium complexes functioned as the noteworthy catalysts for the borohydride mediated reduction of assorted nitro-substrates. Mechanistic studies not only confirmed the intermediacy of [Ru-H] in the reduction but also asserted the involvement of several organic intermediates during the course of the catalysis. A similar Ru(II) complex that lacked pyridine-2,6-dicarboxamide based pincer cavity substantiated its unique role both in the substrate binding and the subsequent catalysis.

Reductive cyanation of organic chlorides using CO2 and NH3 via Triphos–Ni(I) species

Cyano-containing compounds constitute important pharmaceuticals, agrochemicals and organic materials. Traditional cyanation methods often rely on the use of toxic metal cyanides which have serious disposal, storage and transportation issues. Therefore, there is an increasing need to develop general and efficient catalytic methods for cyanide-free production of nitriles. Here we report the reductive cyanation of organic chlorides using CO2/NH3 as the electrophilic CN source. The use of tridentate phosphine ligand Triphos allows for the nickel-catalyzed cyanation of a broad array of aryl and aliphatic chlorides to produce the desired nitrile products in good yields, and with excellent functional group tolerance. Cheap and bench-stable urea was also shown as suitable CN source, suggesting promising application potential. Mechanistic studies imply that Triphos-Ni(I) species are responsible for the reductive C-C coupling approach involving isocyanate intermediates. This method expands the application potential of reductive cyanation in the synthesis of functionalized nitrile compounds under cyanide-free conditions, which is valuable for safe synthesis of (isotope-labeled) drugs.

Synthesis and characterization of a novel TEMPO?FeNi3/DFNS-laccase magnetic nanocomposite for the reduction of nitro compounds

Water is an essential substance for life on earth and for all living things. Plants and animals need almost pure water to live; if it is contaminated with harmful chemicals and micro organisms, it will be impossible for them to survive. This study has tried to investigate the performance of catalyst to reduce nitro-aromatic combinations in the attendance of NaBH4 solution duo to the hydrogen source. TEMPO?FeNi3/DFNS-laccase MNPs was prepared, and its features were reviewed using SEM, TEM, XRD, TGA, VSM, AFM, and FTIR. Then, its strength as a nanocatalyst for removal of nitro-aromatic combinations was tested in contact time, initial concentration, the effects of pH and nanocatalyst amount was study. The results of this research proved that TEMPO?FeNi3/DFNS-laccase MNPs has a good return in removal of nitro-aromatic combinations, as its easy synthesis and reliable recovery.

Generation of Cu nanoparticles on novel designed Fe3O4@SiO2/EP.EN.EG as reusable nanocatalyst for the reduction of nitro compounds

In this work, copper nanoparticles loaded on Fe3O4@SiO2, which we have named Fe3O4@SiO2/EP.EN.EG@Cu for short, have been designed, prepared and characterized by XRD, FTIR, TEM, SEM, EDS, TGA, ICP, successfully. The catalytic performance was investigated in the reduction of aromatic nitro compounds in the presence of NaBH4 aqueous solution as the source of hydrogen at 50°C. The Fe3O4@SiO2/EP.EN.EG@Cu catalyst was readily removed from the reaction mixture by applying an external magnet and reused for five times without significant loss of catalytic activity.

2,4 Diamino benzonitrile

Deep curable polymers having heterocyclic ring systems such as isoindoloquinazolinedione ring systems prepared from novel cyanoimide polymers, most desirably 2'-cyanoimide polymers. Preferably the cyanoimide polymers are prepared from a diamine having at

Compounds, compositions and methods of use

It has now been discovered that novel compounds of FIG. 1 STR1 are useful in the prophylactic treatment of sensitized humans and animals for allergy and all anaphylactic reactions of a reagin or non-reagin mediated nature. Additionally, the compounds are intermediates to the diacid or di salts which have utility in the same area as the esters. The compounds are formulated with pharmaceutical carriers for oral, parenteral, inhalation, or rectal means of administration.