610-30-0

Basic information

• Product Name: 2,4-DINITROBENZOIC ACID
• Synonyms: 2,4-DINITROBENZOIC ACID;LABOTEST-BB LT00455741;RARECHEM AL BO 1413;2,4-DINITROBENZOIC ACID OEKANAL, 250 MG;3,4-Dinitrobenzonitride;2,4-Dinitrobenzoic;2,4-Dinitrobenzoic acid ,99%;2,4-DINITROBENZOIC A
• CAS NO: 610-30-0
• Molecular Formula: C₇H₄N₂O₆
• Molecular Weight: 212.12
• EINECS: 210-219-5
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;C7;Carbonyl Compounds;Carboxylic Acids
• Mol File: 610-30-0.mol
• Article Data: 26

Chemical Properties

• Melting Point: 176-180 °C(lit.)
• Boiling Point: 351.93°C (rough estimate)
• Flash Point: 187.3 °C
• Appearance: /
• Density: 1.688
• Vapor Pressure: 1.48E-07mmHg at 25°C
• Refractive Index: 1.5300 (estimate)
• Storage Temp.: Store below +30°C.
• Solubility: dioxane: 50 mg/mL, clear
• PKA: 1.43(at 25℃)
• Water Solubility: 18.2g/L(25 oC)
• BRN: 658650
• CAS DataBase Reference: 2,4-DINITROBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DINITROBENZOIC ACID(610-30-0)
• EPA Substance Registry System: 2,4-DINITROBENZOIC ACID(610-30-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: DG9140500
• TSCA: Yes
• Hazardous Substances Data: 610-30-0(Hazardous Substances Data)

Usage

Chemical Properties

pale yellow crystalline powder

Uses

Different sources of media describe the Uses of 610-30-0 differently. You can refer to the following data:
1. 2,4-Dinitrobenzoic acid was used in the spectrophotometric determination of diazepam in pure samples and in its pharmaceutical preparations. It was employed as chromophore probe for analysis of perfluorinated carboxylic acids in water by capillary zone electrophoresis. It can be used to produce 2,4-dinitro-benzoyl chloride.
2. 2,4-Dinitrobenzoic acid can be used as a reactant: In decarboxylative C-N cross-coupling reactions. To synthesize Zwitterionic azaspirocyclic hydantoins by reacting with various carbodiimides via in situ intramolecular dearomatization reaction. To prepare 1-(2,4-dinitrophenyl)ethanone by condensation with dimethyl malonate and subsequent decarboxylation reaction.It can also be used in the spectrophotometric determination of diazepam in pure samples and in its pharmaceutical preparations. In capillary zone electrophoresis, it can be employed as chromophore probe for the analysis of perfluorinated carboxylic acids in water.

InChI:InChI=1/C7H4N2O6/c10-7(11)5-2-1-4(8(12)13)3-6(5)9(14)15/h1-3H,(H,10,11)/p-1

Synthetic route

2-amino-4-nitro-6-hydroxy(isopropylbenzene) → 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With 2-(methoxymethoxy)ethanol; trimethylantimony at 50℃; for 4.33333h; Temperature;	97%

2,4-dinitrotoluene (121-14-2) → 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With dihydrogen peroxide In water at 60℃; for 0.5h; Temperature; Sonication;	96.3%
With potassium permanganate; water; magnesium sulfate at 75℃; for 3h; pH=7;	90.7%
With cobalt(II) acetate; ozone; acetic acid at 30℃; Product distribution; Equilibrium constant; Further Variations:; Temperatures; Reagents;	73.8%

2,4-dinitrotoluene (121-14-2) + acetic acid (64-19-7) → Acetic acid (2E,4E)-1-hydroperoxy-5-methyl-2,4-dinitro-6-oxo-hexa-2,4-dienyl ester + 2,4-dinitrobenzaldehyde (528-75-6) + 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With oxygen; ozone at 29.85℃; for 2.5h; Kinetics; Further Variations:; Temperatures;	A 61% B 6% C 28%

N-((5R)-2c-hydroxy-3,3-dimethyl-4t,7-dioxo-(5rH)-4λ4-thia-1-aza-bicyclo[3.2.0]hept-6t-yl)-2-phenyl-acetamide (34103-64-5, 36243-70-6, 41536-84-9, 78779-97-2) + 2,4-dinitrobenzoyl chloride (20195-22-6) → N-[(5R)-2ξ-(2,4-dinitro-benzoyloxy)-3,3-dimethyl-4t,7-dioxo-(5rH)-4λ4-thia-1-aza-bicyclo[3.2.0]hept-6t-yl]-2-phenyl-acetamide (41536-89-4) + 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With pyridine In tetrahydrofuran; benzene	A n/a B 60%

2,6,8,12-tetraacetyl-10-(2,4-dinitrobenzyl)-4-nitro-2,4,6,8,10,12-hexaazatetracyclo[5.5.0.03,11.05,9]dodecane → 2,4-dinitrobenzoic acid (610-30-0) + 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazatetracyclo[5.5.0.03,11.05,9]dodecane

Conditions	Yield
With ammonium nitrate; nitric acid Reflux;	A 31% B 57.2%

1,2-Bis(2,4-dinitrophenyl)ethane (2220-30-6) → 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With perhydrodibenzo-18-crown-6; potassium permanganate In benzene at 20℃; for 5h; Reagent/catalyst; Solvent;	53.86%

2,4-dinitrobenzaldehyde (528-75-6) → 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; laccase from Trametes versicolor; oxygen In water at 20℃; for 144h; Enzymatic reaction;	30%
With silver(I) acetate; acetic acid
With silver nitrate; acetic acid

1-ethyl-2,4-dinitrobenzene (1204-29-1) → 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With nitric acid

2,4-dinitrobenzonitrile (4110-33-2) → 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With sulfuric acid

2-nitro-4-nitroso-benzoic acid (861782-20-9) → 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With nitric acid

2,4-dinitro-benzil-α'-oxime + furan-2,3,5(4H)-trione pyridine (1:1) → benzaldehyde (100-52-7) + 2,4-dinitrobenzoic acid (610-30-0)

1-picryl-pyridinium; nitrate + toluene (108-88-3) → pyridinium picrate (1152-90-5) + 2,4-dinitrobenzoic acid (610-30-0)

4-nitro-benzoic acid (62-23-7) → 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With sulfuric acid; nitric acid

4-nitro-benzoic acid (62-23-7) → 3,4-dinitrobenzoic acid (528-45-0) + 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With sulfuric acid; nitric acid
With sulfuric acid; nitric acid im Druckrohr;

2,4-dinitrobromobenzene (584-48-5) + carbon dioxide (124-38-9) → 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
(i) PhLi, (ii) /BRN= 1900390/; Multistep reaction;

ortho-nitrobenzoic acid (552-16-9) → 2,5-dinitrobenzoic acid (610-28-6) + 2,3-di-nitrobenzoic acid (15147-64-5) + 2,6-dinitrobenzoic acid (603-12-3) + 1,2-Dinitrobenzene (528-29-0) + 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With nitric acid; dinitrogen pentoxide at 25℃; Product distribution; addition of nitronium trifluoromethanesulphonate;

2,4-dinitrotoluene (121-14-2) → 2,4-dinitrobenzaldehyde (528-75-6) + 2,4-dinitrobenzyl alcohol (4836-66-2) + 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With 1,4-dihydronicotinamide adenine dinucleotide; rat liver microsomal and cytosol proteins; NAD In water; acetone at 37℃; Product distribution; phosphate buffer, pH = 7.4; besides of NAD, NADH add of NADP, NADH; add of inhibitor: hydralazine;

ethyl 2,4-dinitro benzoate (33672-95-6) → ethanol (64-17-5) + 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With potassium hydroxide In water; dimethyl sulfoxide at 25℃; Mechanism; Rate constant; Equilibrium constant;

2,4-dinitro-benzoic acid phenyl ester (19081-19-7) → 2,4-dinitrobenzoic acid (610-30-0) + phenol (108-95-2)

Conditions	Yield
With water; 1H-imidazole In acetonitrile at 40℃; Rate constant;
With o-iodosobenzoic acid; water In acetonitrile at 18 - 45℃; Kinetics; Mechanism; Thermodynamic data; ΔH(excit.), ΔS(excit.), ΔG(excit.); determination of catalytic effect of iodosobenzoic acid;

4-nitrophenyl 2,4-dinitrobenzoate (18959-19-8) → 4-nitro-phenol (100-02-7) + 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With water; 1H-imidazole In acetonitrile at 40℃; Rate constant;
With o-iodosobenzoic acid; water In acetonitrile at 18 - 45℃; Kinetics; Mechanism; Thermodynamic data; ΔH(excit.), ΔS(excit.), ΔG(excit.); determination of catalytic effect of iodosobenzoic acid;

C9H16N2*C9H8N3O6(1-)*H(1+) → 2,4-Dinitrophenol (51-28-5) + 2,4-Dinitropropiophenon (61712-88-7) + 10a-Chloro-1-(2,4-dinitro-phenyl)-decahydro-pyrimido[1,2-a]azepine + 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With dihydrogen peroxide; potassium carbonate In water; toluene Yield given;

4-nitrobenzaldehdye (555-16-8) → 2,4-dinitrobenzaldehyde (528-75-6) + 2,4-dinitrobenzoic acid (610-30-0) + 4-nitro-benzoic acid (62-23-7)

Conditions	Yield
With nitric acid; dinitrogen pentoxide at 35℃; Product distribution; Kinetics; Mechanism; other temperature, also with nitronium trifluoromethanesulfonate in nitric acid, relative reactivities of the investigated aldehydes;

2,4-Dinitro-benzoic acid p-tolyl ester (139361-27-6) → p-cresol (106-44-5) + 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With water; 1H-imidazole In acetonitrile at 40℃; Rate constant;
With o-iodosobenzoic acid; water In acetonitrile at 18 - 45℃; Kinetics; Mechanism; Thermodynamic data; ΔH(excit.), ΔS(excit.), ΔG(excit.); determination of catalytic effect of iodosobenzoic acid;

2,4-Dinitro-benzoic acid 4-chloro-phenyl ester (139361-28-7) → 4-chloro-phenol (106-48-9) + 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With water; 1H-imidazole In acetonitrile at 40℃; Rate constant;
With o-iodosobenzoic acid; water In acetonitrile at 18 - 45℃; Kinetics; Mechanism; Thermodynamic data; ΔH(excit.), ΔS(excit.), ΔG(excit.); determination of catalytic effect of iodosobenzoic acid;

2,4-Dinitro-benzoic acid 4-cyano-phenyl ester (139361-29-8) → 4-cyanophenol (767-00-0) + 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With water; 1H-imidazole In acetonitrile at 40℃; Rate constant;
With o-iodosobenzoic acid; water In acetonitrile at 18 - 45℃; Kinetics; Mechanism; Thermodynamic data; ΔH(excit.), ΔS(excit.), ΔG(excit.); determination of catalytic effect of iodosobenzoic acid;

2,4-dinitrobenzoyl chloride (20195-22-6) → 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With 2,3,5-trimethyl-pyridine In water; acetonitrile at 16 - 35℃; Kinetics;

N-(2,4-dinitrobenzoyl)imidazole (80601-68-9) → 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With 1H-imidazole; potassium chloride In water; acetonitrile at 25 - 50℃; Kinetics; Thermodynamic data; ΔH(excit.), ΔS(excit.), ΔG(excit.);

3-(2,4-Dinitro-benzoyl)-1-methyl-3H-imidazol-1-ium; chloride → 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With hydrogenchloride; sodium chloride In water; acetonitrile at 15 - 35℃; Kinetics; Thermodynamic data; ΔH(excit.), ΔS(excit.), ΔG(excit.);

2-Chlor-5,7-dinitro-tropon (20035-23-8) → 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With sodium hydroxide

2-(2,4-dinitro-styryl)-3-methyl-quinoxaline + acetone (67-64-1) + permanganate → 2,4-dinitrobenzoic acid (610-30-0)

(1S)-1-[(2R)-oxiran-2-yl]hexan-1-ol (89408-81-1) + 2,4-dinitrobenzoic acid (610-30-0) → (2R,3R)-(-)-1,2-epoxy-3-octanol 3,5-dinitrobenzoate

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran Ambient temperature; several hours;	99.3%

2,4-dinitrobenzoic acid (610-30-0) + 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane (25015-63-8) → 2-((2,4-dinitrobenzyl)oxy)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Conditions	Yield
In neat (no solvent) at 30℃; Inert atmosphere; Schlenk technique; Glovebox; chemoselective reaction;	99%

2,4-dinitrobenzoic acid (610-30-0) → 2,4-dinitrobenzoyl chloride (20195-22-6)

Conditions	Yield
With thionyl chloride In 1,2-dichloro-ethane for 2h; Heating;	98.8%
With thionyl chloride
With thionyl chloride; chloroform

3-O-methyl-17β-oestradiol (1035-77-4) + 2,4-dinitrobenzoic acid (610-30-0) → 2,4-Dinitro-benzoic acid (8R,9S,13S,14S,17R)-3-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl ester

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In chlorobenzene at 80℃; for 1.5h; Mitsunobu esterification;	98%

cis-bicyclo[3.3.0]octan-endo-2-o1 (24454-38-4) + 2,4-dinitrobenzoic acid (610-30-0) → 2,4-dinitro-benzoic acid octahydro-pentalen-1-yl ester

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; Inert atmosphere;	97%

2,4-dinitrobenzoic acid (610-30-0) + diisopropyl-carbodiimide (693-13-0) → (1,3-diisopropyl-6-nitro-2,4-dioxo-1,3-diazaspiro-[4.5]deca-6,9-dien-1-ium-8-ylidene)azinate

Conditions	Yield
Stage #1: 2,4-dinitrobenzoic acid; diisopropyl-carbodiimide In dichloromethane at 20℃; for 0.5h; Stage #2: With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 16h;	97%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;

1,3-di-tert-butylcarbodiimide (691-24-7) + 2,4-dinitrobenzoic acid (610-30-0) → (1,3-di-tert-butyl-6-nitro-2,4-dioxo-1,3-diazaspiro-[4.5]deca-6,9-dien-1-ium-8-ylidene)azinate

Conditions	Yield
Stage #1: 1,3-di-tert-butylcarbodiimide; 2,4-dinitrobenzoic acid In dichloromethane at 20℃; for 0.5h; Stage #2: With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 16h;	95%

2,4-dinitrobenzoic acid (610-30-0) → meta-dinitrobenzene (99-65-0)

Conditions	Yield
With silver carbonate In dimethyl sulfoxide at 120℃; for 16h;	94%
With copper(l) iodide; triethylamine In dimethyl sulfoxide at 120℃; under 760.051 Torr; for 20h; Inert atmosphere; Schlenk technique;	67%
In water at 172.5℃; Rate constant; Mechanism; Thermodynamic data; kinetics; ΔH(excit.), ΔS(excit.); other substituted dinitrobenzoic acids; other temp.;

(S)-1-phenylbutan-1-ol (22135-49-5) + 2,4-dinitrobenzoic acid (610-30-0) → C17H16N2O6 (1073536-00-1)

Conditions	Yield
With Vilsmeier reagent; triethylamine In tetrahydrofuran at 20℃; for 16h;	94%

p-chlorophenoxymethyl chloride (21151-56-4) + 2,4-dinitrobenzoic acid (610-30-0) → 2,4-Dinitro-benzoic acid 4-chloro-phenoxymethyl ester (83143-90-2)

Conditions	Yield
With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate In dichloromethane for 0.25h; Heating;	93%

dicyclohexyl-carbodiimide (538-75-0) + 2,4-dinitrobenzoic acid (610-30-0) → (1,3-dicyclohexyl-6-nitro-2,4-dioxo-1,3-diazaspiro-[4.5]deca-6,9-dien-1-ium-8-ylidene)azinate

Conditions	Yield
Stage #1: dicyclohexyl-carbodiimide; 2,4-dinitrobenzoic acid In dichloromethane at 20℃; for 0.5h; Stage #2: With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 16h;	93%

(5,5-difluoro-1,3,7,9-tetramethyl-5H-4λ4,5λ4-dipyrrolo[1,2-c:2′,1′-f ][1,3,2]diazaborinin-10-yl)methanol (1256494-55-9) + 2,4-dinitrobenzoic acid (610-30-0) → C21H19BF2N4O6

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 16h; Inert atmosphere;	91%

N-(3-dimethylaminopropyl)-N-ethylcarbodiimide (1892-57-5) + 2,4-dinitrobenzoic acid (610-30-0) → (3-(3-(dimethylamino)propyl)-1-ethyl-6-nitro-2,4-dioxo-1,3-diazaspiro[4.5]deca-6,9-dien-1-ium-8-ylidene)azinate

Conditions	Yield
Stage #1: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 2,4-dinitrobenzoic acid In dichloromethane at 20℃; for 0.5h; Stage #2: With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 16h;	91%

2,4-dinitrobenzoic acid (610-30-0) → 2,4-dinitrobromobenzene (584-48-5)

Conditions	Yield
With Bromotrichloromethane; trichloroisocyanuric acid; bromine at 10 - 120℃; for 18h; Photolysis;	91%

2-phenylethynylphenol (92151-73-0) + 2,4-dinitrobenzoic acid (610-30-0) → (E)-1-(2-hydroxyphenyl)-2-phenylvinyl 2,4-dinitrobenzoate

Conditions	Yield
With bis(1,5-cyclooctadiene)diiridium(I) dichloride In dichloromethane at 20℃; for 12h; regioselective reaction;	91%

tetrakis(acetato)dimolybdenum(II) (14221-06-8, 744215-74-5) + 2,4-dinitrobenzoic acid (610-30-0) → Mo2(O2CC6H3-2,4-(NO2)2)4 (178383-71-6)

Conditions	Yield
In toluene byproducts: AcOH; N2-atmosphere; slight excess of substituted benzoic acid, stirring overnight; solvent removal (vac., gentle warming), repeated addn. of PhMe and evapn., dissoln. in THF, filtration, concn., cooling to -20°C overnight (pptn.);	90%

ammonium hydroxide (1336-21-6) + oxalyl dichloride (79-37-8) + 2,4-dinitrobenzoic acid (610-30-0) → 2,4-dinitrobenzamide (13296-87-2)

Conditions	Yield
	89%

2,2,2-Trinitroethyl hydrogen sulfate (66881-27-4) + 2,4-dinitrobenzoic acid (610-30-0) → 2,4-Dinitro-benzoic acid 2,2,2-trinitro-ethyl ester

Conditions	Yield
at 50 - 55℃; for 1h;	88%

1,3-di-tert-butylcarbodiimide (691-24-7) + 2,4-dinitrobenzoic acid (610-30-0) → N-(tert-butyl)-N-(tert-butylcarbamoyl)-2,4-dinitrobenzamide

Conditions	Yield
In dichloromethane at 20℃;	88%

Cyclopentanol (96-41-3) + 2,4-dinitrobenzoic acid (610-30-0) → C12H12N2O6 (1073535-97-3)

Conditions	Yield
With Vilsmeier reagent; triethylamine In tetrahydrofuran at 20℃; for 16h;	87%

(+)-(S)-4-phenylbutan-2-ol (2344-70-9, 14786-43-7, 39516-03-5, 22148-86-3) + 2,4-dinitrobenzoic acid (610-30-0) → C17H16N2O6 (1073536-01-2)

Conditions	Yield
With Vilsmeier reagent; triethylamine In tetrahydrofuran at 20℃; for 16h;	86%

4-[5-(naphtho[2,1-b]furan-2-yl)-1,3,4-oxadiazol-2-yl]aniline + 2,4-dinitrobenzoic acid (610-30-0) → N-(4-(5-(naphtho[2,1-b]furan-2-yl)-1,3,4-oxadiazol-2-yl)phenyl)-2,4-dinitrobenzamide

Conditions	Yield
Stage #1: 4-[5-(naphtho[2,1-b]furan-2-yl)-1,3,4-oxadiazol-2-yl]aniline With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 20℃; Inert atmosphere; Stage #2: 2,4-dinitrobenzoic acid In dichloromethane at 20℃; Inert atmosphere;	86%

2,4-dinitrobenzoic acid (610-30-0) + allyltriisopropylsilane oxide (205931-93-7, 198965-04-7) → 2-(2,4-dinitrobenzoyloxy)-3-triisopropylsilyl-1-propanol

Conditions	Yield
In chloroform	85%

1,2,3-Benzotriazole (95-14-7) + 2,4-dinitrobenzoic acid (610-30-0) → (1H-benzo[d][1,2,3]triazol-1-yl)(2,4-dinitrophenyl)methanone

Conditions	Yield
With thionyl chloride In dichloromethane at 20℃; for 8.5h;	83%
With thionyl chloride In dichloromethane at 20℃;

N,N-dimethyl-formamide (68-12-2, 33513-42-7) + 2,4-dinitrobenzoic acid (610-30-0) → N,N-dimethyl-2,4-dinitrobenzamide

Conditions	Yield
With trichlorophosphate at 120℃; for 1h; Sealed tube;	83%
With trichlorophosphate at 120℃; for 1h;	83%

2-diazo-1-(3-phenyl-2H-azirin-2-yl)ethan-1-one + 2,4-dinitrobenzoic acid (610-30-0) → 2-oxo-2-(3-phenyl-2H-azirin-2-yl)ethyl 2,4-dinitrobenzoate

Conditions	Yield
In dichloromethane at 0 - 20℃;	83%

glycerol (56-81-5) + 2,4-dinitrobenzoic acid (610-30-0) → 1,3-dichloro-2-propyl 2,4-dinitrobenzoate (1203507-38-3)

Conditions	Yield
With chloro-trimethyl-silane at 80℃; for 48h;	81%

diphenylsilyl dichloride (80-10-4) + 2,4-dinitrobenzoic acid (610-30-0) → C26H16N4O12Si (129459-89-8)

Conditions	Yield
In benzene at -20℃; for 6h;	80.5%

Upstream product

• 121-14-2 2,4-dinitrotoluene 
• 108-88-3 toluene 
• 62-23-7 4-nitro-benzoic acid 
• 33672-95-6 ethyl 2,4-dinitro benzoate 
• 7664-93-9 sulfuric acid 
• 7697-37-2 nitric acid 
• 528-75-6 2,4-dinitrobenzaldehyde 
• 61599-68-6 1,3,5-trinitro-2-[(E)-2-phenylvinyl]benzene 
• 861782-20-9 2-nitro-4-nitroso-benzoic acid 
• 853787-40-3 2,4,6,2',4'-Pentanitro-benzil 
• 681466-48-8 N-(2,4-dinitro-phenethyl)-acetamide 
• 6279-98-7 1,6-bis-(2,4-dinitro-phenyl)-hexane 
• 64-19-7 acetic acid 
• 7722-84-1 dihydrogen peroxide 

Downstream Products

• 129459-89-8 C₂₆H₁₆N₄O₁₂Si 
• 108-45-2 m-phenylenediamine 
• 124-38-9 carbon dioxide 
• 125791-82-4 2,4-Dinitrobenzoic acid, 7-hydroxycoumarin ester 
• 37705-82-1 2,4-diaminobenzonitrile 
• 711007-44-2 2,3-diaminobenzamide 
• 178383-71-6 Mo₂(O₂CC₆H₃-2,4-(NO₂)2)4 
• 1203507-38-3 1,3-dichloro-2-propyl 2,4-dinitrobenzoate 
• 1203507-40-7 2,3-dichloro-1-propyl 2,4-dinitrobenzoate 
• 466685-24-5 C₁₃H₁₅N₃O₇ 
• 1408304-10-8 [Co(1,10-phenanthroline)2CO3](2,4-dinitrobenzoate)·H2O 
• 1585988-47-1 benzyl 2-(2,4-dinitrobenzamido)acetate 
• 670230-30-5 2-(2,4-dinitrobenzamido)acetic acid 
• 83707-84-0 (S)-2-(2,4-dinitrobenzamido)propanoic acid 

Relevant articles and documents

BODIPY-Derived Photoremovable Protecting Groups Unmasked with Green Light

Photoremovable protecting groups derived from meso-substituted BODIPY dyes release acetic acid with green wavelengths >500 nm. Photorelease is demonstrated in cultured S2 cells. The photocaging structures were identified by our previously proposed strategy of computationally searching for carbocations with low-energy diradical states as a possible indicator of a nearby productive conical intersection. The superior optical properties of these photocages make them promising alternatives to the popular o-nitrobenzyl photocage systems.

Continuous production method of benzoic acid derivative

The invention relates to the technical field of preparation of benzoic acid derivatives. The invention particularly relates to a continuous production method of a benzoic acid derivative. The continuous reaction device is characterized by comprising a small-diameter sleeve, wherein the small-diameter sleeve is sleeved with a large-diameter sleeve, and a small pipeline is arranged between the small-diameter sleeve and the large-diameter sleeve, and a plurality of small holes are arranged on the small pipeline. The small-diameter casing is rotated, the large-diameter casing is fixed, and the reaction liquid composed of the nitric acid and the toluene derivative is between a small-diameter casing pipe and a large-diameter casing pipe.

Preparation method of important intermediate 2,4-difluorobenzoic acid

The invention discloses a preparation method of 2,4-difluorobenzoic acid. The preparation method comprises steps as follows: 2,4-dinitrotoluene and water are mixed, a prepared TS-1 molecular sieve isadded, the mixture is mixed uniformly, the temperature i