3771-14-0

Usage

Uses

Used in Dye and Pigment Synthesis:
4-hydroxynaphthalene-2-sulphonic acid is used as an intermediate in the synthesis of dyes and pigments for its ability to contribute to the color and stability of these compounds.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 4-hydroxynaphthalene-2-sulphonic acid is utilized as a key intermediate in the production of various drugs, highlighting its importance in the development of medicinal compounds.
Used as a pH Indicator:
4-hydroxynaphthalene-2-sulphonic acid serves as a pH indicator due to its ability to change color in response to different pH levels, making it useful for monitoring acidity or alkalinity in solutions.
Used as a Fluorescent Dye in Research:
In biological and chemical research, 4-hydroxynaphthalene-2-sulphonic acid is employed as a fluorescent dye, allowing for the visualization and tracking of specific molecules or cellular structures under ultraviolet light.
It is crucial to handle and store 4-hydroxynaphthalene-2-sulphonic acid with care, as it can be harmful if ingested or inhaled and can cause irritation to the skin and eyes.

InChI:InChI=1/C10H8O4S/c11-10-6-8(15(12,13)14)5-7-3-1-2-4-9(7)10/h1-6,11H,(H,12,13,14)

Upstream product

• 64-17-5 ethanol 
• 34154-00-2 8-hydroxy-6-sulfo-naphthalene-2-diazonium-betaine 
• 90-51-7 6-amino-4-hydroxy-2-naphthalenesulfonic acid 
• 117-43-1 8-hydroxy-naphthalene-1,6-disulfonic acid 
• 86-65-7 2-aminonaphthalene-6,8-disulfonate 
• 15119-80-9 4-oxo-1,2,3,4-tetrahydro-naphthalene-2-sulfonic acid 
• 134-54-3 4-aminonaphthalene-2-sulfonic acid 
• 7732-18-5 water 
• 6094-26-4 naphthalene-1,3-disulfonic acid 
• 860363-74-2 6-hydrazino-4-hydroxy-naphthalene-2-sulfonic acid 
• 7758-99-8 copper(II) sulfate 
• 1542203-80-4 1-octanoyloxynaphthalene-3-sulfonic acid 

Downstream Products

• 109156-09-4 4-hydroxy-3-(4-nitro-phenylazo)-naphthalene-2-sulfonic acid 
• 25107-88-4 4-hydroxy-1-(4-nitro-phenylazo)-naphthalene-2-sulfonic acid 
• 4531-72-0 3-(4-chloro-phenylazo)-4-hydroxy-naphthalene-2-sulfonic acid 
• 109156-08-3 4-hydroxy-3-(2-nitro-phenylazo)-naphthalene-2-sulfonic acid 
• 109156-10-7 4-hydroxy-1-(2-nitro-phenylazo)-naphthalene-2-sulfonic acid 
• 24824-28-0 naphthalene-1,3-diamine 
• 1254576-59-4 C₄₈H₃₈N₄O₁₁S₂ 
• 1254103-31-5 C₃₁H₂₆N₂O₅S 
• 1215771-99-5 C₄₁H₃₂N₄O₈S₂ 
• 118-90-1 ortho-methylbenzoic acid 

Relevant academic research and scientific papers

A chromogenic substrate for solid-phase detection of phospholipase A 2

A method for solid-phase detection of phospholipase A2 (PLA 2) was developed. The method uses 1-octanoyloxynaphthalene-3-sulfonic acid, which was found to be a good substrate of PLA2. The substrate is hydrolyzed by PLA2 into 1-naphthol-3-sulfonic acid, which is spontaneously coupled with coexisting diazonium salt to form a red-purple azo dye. Streptomyces and bovine pancreatic PLA2 spotted on a nitrocellulose membrane could be detected by this method with considerable sensitivity. In addition, colonies of recombinant Escherichia coli producing bacterial PLA2 were distinguishable from those producing an inactive mutant PLA2, facilitating high-throughput screening in directed evolution of the enzyme.

Process for aryl-quinone and aryl-naphthoquinone diazide sulfonic acids

A process for the preparation of aryl-diazide-sulfonic acids by a series of sequential in-situ process steps. The process comprises the nitrosation of a hydroxyarylsulfonic acid; conversion of the nitroso-derivative to a sulfamate which is then diazotized to the diazide. Temperature and pH are maintained in predetermined ranges to maintain the reaction products in solution without the formation side-products or the need to isolate intermediates. The process of the invention is particularly useful in the preparation of light-sensitive materials such as naphthoquinonediazide sulfonic acids which are used in the preparation of photoresist compositions. The invention provides a high purity product at a high material efficiency, high equipment utilization, low effluent discharge, and reduced cost.