37722-51-3Relevant academic research and scientific papers
Application of ionic liquids in enzymic resolution by hydrolysis of cycloalkyl acetates
Xanthakis, Epameinondas,Zarevucka, Marie,Saman, David,Wimmerova, Martina,Kolisis, Fragiskos N.,Wimmer, Zdenek
, p. 2987 - 2992 (2007/10/03)
A comparative study was performed in the enzymic resolution of the isomers of 2-(4-methoxybenzyl)cyclohexyl acetates 1 and 2. The investigation consisted in application of three commercially available lipases (Novozyme 435, Lipozyme IM and non-immobilized
Synthesis and structure-activity relationships of juvenoids derived from 2-(4-hydroxybenzyl)cycloalkan-1-ones
Rejzek,Wimmer,Saman,Ricankova,Nemec
, p. 1241 - 1255 (2007/10/02)
Juvenoids 16-30, 32, 36, 38-41, 44-46, and 49-56 containing carbamate, carbonate, and urea moieties in the molecule were synthesized and subjected to a biological screening. Carbamate juvenoids 1-4 were used as reference compounds for a detailed structure-activity study of their analogues. A clear relationship between the nature of the side chain functional group and the biological activity was found. Surprisingly, not only the juvenoids 1,4 but also 38-41, the compounds with a reversed carbamate N,O-substitution pattern, showed very promising biological activity. In contrast, the carbonate and urea derivatives displayed a remarkably low activity. The relationship between the size and substitution at atoms C(2) and C(3) of the saturated ring and the biological activity is very complex and is still not completely understood.
CONFORMATION STUDIES OF ISOMERIC 1-ACYLOXY-2-(4-METHOXYBENZYL)-CYCLOHEXANES BY 1H NMR SPECTTOSCOPY
Budesinsky, Milos,Saman, David,Wimmer, Zdenek
, p. 2763 - 2767 (2007/10/02)
The conformation of the cyclohexane ring and the p-methoxybenzyl substituent in the series of isomeric 1-acyloxy-2-(4-methoxybenzyl)cyclohexanes was studied by means of 1H NMR spectroscopy.In all the substances investigated the cyclohexane ring assumes ch
