37722-81-9Relevant academic research and scientific papers
Reductive Cyclization of Ketoesters Utilizing Sodium Cyanoborohydride: Synthesis of γ- and δ-Lactones
Podraza, Kenneth F.
, p. 293 - 295 (2007/10/02)
A new one pot procedure to synthesize γ- and δ-lactones, in a 76-84percent yield, is accomplished by the reductive cyclization of 1,4- and 1,5-ketoesters, utilizing sodium cyanoborohydride.The procedure is generally applicable to a wide variety of ketoesters with the exception of the ethyl ester of alkyl 1,5-ketoesters and α,β-unsaturated 1,4- and 1,5-ketoesters.
