37758-41-1

Basic information

• Product Name: Thiophene, 2-(2-nitro-2-phenylethenyl)-, (E)-
• CAS NO: 37758-41-1
• Molecular Formula: C12H9NO2S
• Molecular Weight: 231.275
• Mol File: 37758-41-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Thiophene, 2-(2-nitro-2-phenylethenyl)-, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: Thiophene, 2-(2-nitro-2-phenylethenyl)-, (E)-(37758-41-1)
• EPA Substance Registry System: Thiophene, 2-(2-nitro-2-phenylethenyl)-, (E)-(37758-41-1)

Safety Data

• Hazardous Substances Data: 37758-41-1(Hazardous Substances Data)

Upstream product

• 960211-66-9 (Z)-2-(2-bromo-2-nitrovinyl)thiophene 
• 98-80-6 phenylboronic acid 
• 98-03-3 thiophene-2-carbaldehyde 
• 622-42-4 1-nitro-1-phenylmethane 

Downstream Products

• 95838-51-0 2-Acetyl-4-aci-nitro-4-phenyl-3-(2-thienyl)butansaeure-ethylester 
• 107389-27-5 3-Acetyl-5-aci-nitro-5-phenyl-4-(2-thienyl)-2-pentanon 
• 95838-32-7 2-Methyl-5-phenyl-4-(2-thienyl)-3-pyrrolcarbonsaeure-ethylester 
• 107389-37-7 5-Acetyl-5,6-dihydro-6-hydroxy-6-methyl-3-phenyl-4-(2-thienyl)-4H-1,2-oxazin 
• 42748-04-9 5-phenyl-4H-thieno[3,2-b]pyrrole 

Relevant articles and documents

Palladium-Catalyzed Intramolecular Cyclization of Nitroalkenes: Synthesis of Thienopyrroles

In the presence of carbon monoxide, the palladium/phenanthroline system catalyzes the intramolecular amination of thiophene rings following the reduction of a nitroalkene moiety directly attached to the S-heterocyclic ring. Optimization of the ligand and reaction conditions allowed the synthesis of a series of thienopyrroles aryl/alkyl-substituted at either the 2- or 3-position of the pyrrole ring. By using low pressures of carbon monoxide (5 bars), high yields of fused bicyclic compounds have been obtained (up to 98 % yield).